Current Protocols

Editors & Contributors

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EDITORIAL BOARD

S.J. Enna (Editor-in-Chief)
University of Kansas Medical Center
Kansas City, Kansas

Michael Williams (Editor-in-Chief)
Cephalon
West Chester, Pennsylvania

John W. Ferkany
Surface Logix
Brighton, MA

Terry Kenakin
GlaxoSmithKline
Research Triangle Park, North Carolina

Paul Moser
Porsolt and Partners Pharmacology
Boulonge Billancourt, France

Bruce Ruggeri
Cephalon
West Chester, Pennsylvania

PAST EDITORS

John F. Barrett
Merck Research Laboratories
Rahway, New Jersey

Roger D. Porsolt
Porsolt and Partners Pharmacology
Boulonge Billancourt, France

James P. Sullivan
Abbott Laboratories
Abbott Park, Illinois

CONTRIBUTORS

Worku Abebe
East Carolina University
Greenville, North Carolina

Susan M. Abmayr
Pennsylvania State University
University Park, Pennsylvania

Daniel H. Albert
Abbott Laboratories
Abbott Park, Illinois

Pēteris Alberts
Biovitrum
Stockholm, Sweden

Stephen P.H. Alexander
University of Nottingham Medical School
Nottingham, United Kingdom

Richard H. Alper
University of Kansas School of Medicine
Kansas City, Kansas

Charles Anderson
Discovery Biology
Pfizer Central Research
Sandwich, United Kingdom

David J. Anderson
Abbott Laboratories
Abbott Park, Illinois

Paul Aravich
Eastern Virginia Medical School and Veterans Affairs Medical Center
Norfolk and Hampton, Virginia

Kenneth L. Audus
University of Kansas
Lawrence, Kansas

Daniel Auld
Douglas Hospital Research Center and McGill University
Montreal, Canada

Anthony W. Bannon
Amgen, Inc.
Thousand Oaks, California

Melissa S. Beck-Westermeyer
University of Kansas
Lawrence, Kansas

Bernard Beer
DOV Pharmaceutical
Hackensack, New Jersey

Marie K. Hoeger Bement
University of Iowa
Iowa City, Iowa

Dietmar Benke
University of Zurich
Zurich, Switzerland

Gary J. Bennett
McGill University
Montreal, Canada

Kelly A. Berg
University of Texas Health Science Center
San Antonio, Texas

Daniel Bertrand
Centre Médical Universitaire
Geneva, Switzerland

Sonia Bertrand
Centre Médical Universitaire
Geneva, Switzerland

Ilona Berzetei-Gurske
SRI International
Menlo Park, California

W. Robert Bishop
Schering-Plough Research Institute
Kenilworth, New Jersey

Kathleen M.K. Boje
University of Buffalo, School of Pharmacology
Buffalo, New York

Ronald T. Borchardt
University of Kansas
Lawrence, Kansas

H. Neal Bramson
GlaxoSmithKline
Research Triangle Park, North Carolina

Allan R. Brasier
University of Texas
Galveston, Texas

Timothy J. Brennan
University of Iowa College of Medicine
Iowa City, Iowa

Geneviève Brossard
Porsolt and Partners Pharmacology
Boulogne-Billancourt, France

Neil Brunton
Discovery Biology
Pfizer Central Research
Sandwich, United Kingdom

Lorrene A. Buckley
Lilly Research Laboratories
Indianapolis, Indiana

Stephen Buratowski
Harvard Medical School
Boston, Massachusetts

David J. Burns
Abbott Laboratories
Abbott Park, Illinois

Mark Bushfield
Cambridge Drug Discovery
Cambridge, United Kingdom

David B. Bylund
University of Nebraska Medical Center
Omaha, Nebraska

Brendan J. Canning
The Johns Hopkins Medical Institutions
Baltimore, Maryland

Galen Carey
Schering-Plough Research Institute
Kenilworth, New Jersey

Andrés E. Carrasceo
Buenos Aires Medical School
Buenos Aires, Argentina

Kevin M. Carrick
GlaxoSmithKline
Research Triangle Park, North Carolina

Michael J. Carrozza
Pennsylvania State University
University Park, Pennsylvania

Anthony Carter
Discovery Biology
Pfizer Central Research
Sandwich, United Kingdom

Joel A. Cassel
Adolor Corporation
Exton, Pennsylvania

James V. Cassella
Neurogen Corporation
Branford, Connecticut

Neil A. Castle
Icagen
Durham, North Carolina

Icilio Cavero
Bonneuil sur Marne, France

Jean-Guy Chabot
Douglas Hospital Research Center and McGill University
Montreal, Canada

Leslie J. Charles
3M Pharmaceuticals
St. Paul, Minnesota

June Chen
Allergan
Irvine, California

Lewis A. Chodosh
University of Pennsylvania
Philadelphia, Pennsylvania

Agnes Choppin
Roche Bioscience
Palo Alto, California

Arthur Christopoulos
University of Melbourne
Victoria, Australia

Jin Mo Chung
Marine Biomedical Institute
Galveston, Texas

Dennis J. Church
Serono Pharmaceutical Research Institute
Plan-les-Ouates, Switzerland

Jill Clampit
Abbott Laboratories
Abbott Park, Illinois

William P. Clarke
University of Texas Health Science Center
San Antonio, Texas

Donald M. Coen
Harvard Medical School
Boston, Massachusetts

Robert A. Coleman
Pharmagene Laboratories
Royston, United Kingdom

Alex C. Conner
Aston University
Aston Triangle, United Kingdom

Mauro Corsi
Glaxo Wellcome S.p.A.
Verona, Italy

Bryan F. Cox
Abbott Laboratories
Abbott Park, Illinois

Richard F. Cox
GlaxoSmithKline
Research Triangle Park, North Carolina

Mark Crawford
CEREP
Rueil-Malmaison, France

Stephen L. Crooks
3M Pharmaceuticals
St. Paul, Minnesota

William J. Crumb
Zenas Technologies
New Orleans, Louisiana

Brian S. Cummings
Medical University of South Carolina
Charleston, South Carolina

Stacie A. Dalrymple
Roche Bioscience
Palo Alto, California

Alex Daniels
Glaxo Wellcome Research and Development
Research Triangle Park, North Carolina

Gavin Davey
Trinity College
Dublin, Ireland

Steven K. Davidsen
Abbott Laboratories
Abbott Park, Illinois

Michael W. Decker
Abbott Laboratories
Abbott Park, Illinois

Robert N. DeHaven
Adolor Corporation
Exton, Pennsylvania

Diane L. DeHaven-Hudkins
Adolor Corporation
Exton, Pennsylvania

Enock Delaporte
Merck Research Laboratories
West Point, Pennsylvania

Chengjun Deng
Memory Pharmaceuticals
Montvale, New Jersey

Errol B. De Souza
Neurocrine Biosciences
San Diego, California

Michael De Vivo
Memory Pharmaceuticals
Montvale, New Jersey

Xiao-Wei Dong
Schering-Plough Research Institute
Kenilworth, New Jersey

Michael A. Dorato
Lilly Research Laboratories
Indianapolis, Indiana

Sylvain Doré
Douglas Hospital Research Center and McGill University
Montreal, Canada

Natasha Dow
Covance
Madison, Wisconsin

Joffrey Ducroq
Université de Caen
Boulogne-Billancourt, France

Nicola Duggan
Neurocrine Biosciences
San Diego, California

Ronald S. Duman
Yale University School of Medicine
Connecticut Mental Health Center
New Haven, Connecticut

Thomas V. Dunwiddie
Veterans Administration Medical Research Service
Denver, Colorado

Nicholas Dürmüller
Porsolt and Partners Pharmacology
Boulogne-Billancourt, France

Richard M. Eglen
Roche Bioscience
Palo Alto, California

S.J. Enna
University of Kansas Medical Center
Kansas City, Kansas

Michael Entzeroth
S*BIO Pte
Singapore

Timothy A. Esbenshade
Abbott Laboratories
Abbott Park, Illinois

Nicholas Evans
GlaxoSmithKline Research
Harlow, United Kingdom

John Ferkany
Preclinical Associates Ltd.
Glastonbury, Connecticut

Katherine W. Figueroa
Johnson and Johnson Pharmaceutical
La Jolla, California

Sandra E. File
King ‘s College London
London, United Kingdom

John J. Fortin
Tropix
Bedford, Massachusetts

Gerard B. Fox
Abbott Laboratories
Abbott Park, Illinois

Alan Frazer
The Audie L. Murphy Memorial Hospital Division
University of Texas Health Science Center
San Antonio, Texas

Christelle Froger
Porsolt and Partners Pharmacology
Boulogne-Billancourt, France

Eric S. Furfine
Glaxo Wellcome Research and Development
Research Triangle Park, North Carolina

Sean Gallagher
Motorola Phoenix Applied Research Center
Tempe, Arizona

Jinnian Gao
University of Kansas
Lawrence, Kansas

G. F. Gebhart
University of Iowa
Iowa City, Iowa

William J. Giardina
Abbott Laboratories
Abbott Park, Illinois

James K. Gierse
Searle Research and Development
Chesterfield, Missouri

Gary A. Gintant
Abbott Laboratories
Abbott Park, Illinois

Aaron S. Goetz
GlaxoSmithKline
Research Triangle Park, North Carolina

Ronald L. Goldberg
Novartis Institute of Biomedical Research
Summit, New Jersey

Murali Gopalakrishnan
Abbott Laboratories
Abbott Park, Illinois

Georgianna Gould
University of Texas Health Science Center
San Antonio, Texas

Dimitri E. Grigoriadis
Neurocrine Biosciences
San Diego, California

Garrett J. Gross
Medical College of Wisconsin
Milwaukee, Wisconsin

Philippe Guillaume
Porsolt and Partners Pharmacology
Le Kremlin-Bicêtre Cedex, France

Clarence Hale
Amgen
Thousand Oaks, California

Petro Halkowycz
Memory Pharmaceuticals
Montvale, New Jersey

Arthur A. Hancock
Abbott Laboratories
Abbott Park, Illinois

Anna G. Haramis
EMBL
Heidelberg, Germany

Wallace Harrington
Glaxo Wellcome Research and Development
Research Triangle Park, North Carolina

David A. Hartman
Ricerca
Concord, Ohio

Carine Hautbois
Porsolt and Partners Pharmacology
Boulogne-Billancourt Cedex, France

Brian E. Hawes
Schering-Plough Research Institute
Kenilworth, New Jersey

Anne-Marie Hay
Porsolt and Partners Pharmacology
Le Kremlin-Bicêtre Cedex, France

Debbie L. Hay
Aston University
Aston Triangle, United Kingdom

Douglas W. P. Hay
SmithKline Beecham Pharmaceuticals
King of Prussia, Pennsylvania

Sharath S. Hegde
Roche Bioscience
Palo Alto, California

Bridget T. Hill
Centre de Recherche Pierre Fabre
Castres, Cedex, France

Jeanette R. Hill
Ricerca Biosciences
Concord, Ohio

Diane C. Hoffman
Neurogen Corporation
Branford, Connecticut

Melinda Hollingshead
National Cancer Institute
Frederick, Maryland

Paul Honegger
Universite de Lausanne
Lausanne, Switzerland

Marie Honore
Abbott Laborotories
Abbott Park, Illinois

Isabelle Hubert
Porsolt and Partners Pharmacology
Le Kremlin-Bicêtre, France

Erin D. Hugger
University of Kansas
Lawrence, Kansas

Diane M. Ignar
GlaxoSmithKline
Research Triangle Park, North Carolina

Michael F. Jarvis
Abbott Laboratories
Abbott Park, Illinois

Michael R. Jirousek
Abbott Laboratories
Abbott Park, Illinois

Bo G. Johansson
Somedic
Hörby, Sweden

R. Carter W. Jones, III
University of Iowa
Iowa City, Iowa

Robert L. Jones
The Chinese University of Hong Kong
Shatin, Hong Kong

Jason A. Kahana
Dana-Farber Cancer Institute
Boston, Massachusetts

R.H. Kant
AccuScan/Omnitech Instruments
Columbus, Ohio

Satyabrata Kar
Douglas Hospital Research Center and McGill University
Montreal, Canada

William Karbon
Amgen
Thousand Oaks, California

Vladimir V. Karpitskiy
Washington University School of Medicine
St. Louis, Missouri

D. Nedra Karunaratne
University of Kansas
Lawrence, Kansas

David A. Katz
Abbott Laboratories
Abbott Park, Illinois

Zehra Kaymakcalan
Abbott Bioresearch Center
Worcester, Massachusetts

Lois J. Kehl
University of Minnesota
Minneapolis, Minnesota

John H. Kehne
Neurogen Corporation
Branford, Connecticut

John J. Kelly
University of South Alabama College of Medicine
Mobile, Alabama

Terry Kenakin
GlaxoSmithKline
Research Triangle Park, North Carolina

David Kendall
University of Nottingham Medical School
Nottingham, United Kingdom

Barry Kenny
Cambridge Drug Discovery
Cambridge, United Kingdom

Robert E. Kingston
Massachusetts General Hospital and Harvard Medical School
Boston, Massachusetts

Patrick Kitabgi
Hopital St-Antoine
Paris, France

Carol M. Koboldt
Searle Research and Development
Chesterfield, Missouri

Martha F. Kramer
Harvard Medical School
Boston, Massachusetts

Anna Kruczynski
Centre de Recherche Pierre Fabre
Castres, Cedex, France

Michael J. Kuhar
Yerkes Regional Primate Research Center
Atlanta, Georgia

Pierre Lacroix
Porsolt and Partners Pharmacology
Boulogne Billancourt, France

Nathaniel R. Landau
The Salk Institute for Biological Studies
La Jolla, California

Kathleen M. Lee
Scios
Sunnyvale, California

Martine Lemaire
Porsolt and Partners Pharmacology
Boulogne-Billancourt, France

James M. Lenhard
GlaxoSmithKline
Research Triangle Park, North Carolina

Beth Levant
University of Kansas Medical Center
Kansas City, Kansas

Jeffrey Liebman
Novartis Institute of Biomedical Research
Summit, New Jersey

Arnold S. Lippa
DOV Pharmaceutical
Hackensack, New Jersey

Morgan T. Lippa
DOV Pharmaceutical
Hackensack, New Jersey

Yong Liu
Pfizer Global Research & Development
Ann Arbor, Michigan

John P. Long
University of Iowa
Iowa City, Iowa

Marge T. Lorang
Neurocrine Biosciences
San Diego, California

Rex Lovrien
University of Minnesota
St. Paul, Minnesota

Thomas Lubben
Abbott Laboratories
Abbott Park, Illinois

Mark A. Luttmann
SmithKline Beecham Pharmaceuticals
King of Prussia, Pennsylvania

Simon J. Lydford
Molecular Devices
Winnersh, United Kingdom

Matthias Mack
Ludwig-Maximilians-University of Munich
Munich, Germany

Carlo Alberto Maggi
Menarini Ricerche
Florence, Italy

Rafael Maldonado
University Pompeu Fabra
Barcelona, Spain

Julie Marasco
Amgen
Thousand Oaks, California

Patrick A. Marcotte
Abbott Laboratories
Abbott Park, Illinois

Shelby A. Martensen
GlaxoSmithKline
Research Triangle Park, North Carolina

Graeme R. Martin
Telik
South San Francisco, California

Daumantas Matulis
University of Minnesota
St. Paul, Minnesota

Stuart B. Mazzone
University of Melbourne
Victoria, Australia

Robert A. McArthur
McArthur and Associates GmbH
Basel, Switzerland

Dale E. McCall
DuPont Merck Pharmaceuticals
Wilmington, Delaware

Kenneth E. McCarson
University of Kansas Medical Center
Kansas City, Kansas

Michael McKinney
Mayo Clinic Jacksonville
Jacksonville, Florida

Christopher Mehlin
University of Washington
Seattle, Washington

Ashok K. Mehta
The University of Texas Health Science Center
San Antonio, Texas

Alison Miller
Discovery Biology
Pfizer Central Research
Sandwich, United Kingdom

Laurence J. Miller
Mayo Clinic
Rochester, Minnesota

Ali-Reza Modiri
Biovitrum
Stockholm, Sweden

Hanns Mohler
University of Zurich
Zurich, Switzerland

Eduardo J. Molinari
Abbott Laboratories
Abbott Park, Illinois

David Moore
Baylor College of Medicine
Houston, Texas

Jeanne Morgan
Boehringer Ingelheim Pharmaceuticals
Ridgefield, Connecticut

Magda F. Morton
Johnson & Johnson Pharmaceutical
La Jolla, California

Jan Mos
Solvay Pharmaceuticals B.V.
Weesp, The Netherlands

Martha Motherway
Trinity College
Dublin, Ireland

Roseanna M. Muccitelli
SmithKline Beecham Pharmaceuticals
King of Prussia, Pennsylvania

Carsten Münk
The Salk Institute for Biological Studies
La Jolla, California

Dennis J. Murphy
GlaxoSmithKline Pharmaceuticals
King of Prussia, Pennsylvania

Donna Mussatto
Abbott Laboratories
Abbott Park, Illinois

S. Jamal Mustafa
East Carolina University
Greenville, North Carolina

Norman Nash
Acadia Pharmaceuticals
San Diego, California

Donald Newgreen
Discovery Biology
Pfizer Central Research
Sandwich, United Kingdom

Wende Niforatos
Abbott Laboratories
Abbott Park, Illinois

John L. Nitiss
St. Jude Children ‘s Research Hospital
Memphis, Tennesee

Philip Nunn
Discovery Biology
Pfizer Central Research
Sandwich, United Kingdom

Berend Olivier
Utrecht University
Utrecht, The Netherlands and
Yale University School of Medicine
New Haven, Connecticut and
PsychoGenics
Hawthorne, New York

Emmanuel T. Onua
DeCODE Genetics
Woodridge, Illinois

Mark A. Osinski
Abbott Laboratories
Abbott Park, Illinois

Mariusz Papp
Polish Academy of Sciences
Krakow, Poland

Riccardo Patacchini
Menarini Ricerche
Florence, Italy

Mark A. Paulik
GlaxoSmithKline
Research Triangle Park, North Carolina

Didier Pélaprat
Hopital St-Antoine
Paris, France

Mary Ann Pelleymounter
Neurocrine Biosciences
San Diego, California

Scott Perschke
NovaScreen Bioscience Corporation
Hanover, Maryland

Sandra Picard
Porsolt and Partners Pharmacology
Boulogne-Billancourt, France

R. D. Porsolt
Porsolt and Partners Pharmacology
Boulogne-Billancourt, France

Christine A. Power
Serono Pharmaceutical Research Institute
Plan-les-Ouates, Switzerland

David R. Poyner
Aston University
Aston Triangle, United Kingdom

Clodagh E. Prendergast
Johnson & Johnson Pharmaceutical
La Jolla, California

Tony Priestley
Schering-Plough Research Institute
Kenilworth, New Jersey

William R. Proctor
Veterans Administration Medical Research Service
Denver, Colorado

Amanda E. I. Proudfoot
Serono Pharmaceutical Research Institute
Plan-les-Ouates, Switzerland

Remi Quirion
Douglas Hospital Research Center
Montreal, Canada

Rajan Radhakrishnan
University of Iowa
Iowa City, Iowa

Vincent Rash
GlaxoSmithKline
Research Triangle Park, North Carolina

Glenn A. Reinhart
Abbott Laboratories
Abbott Park, Illinois

Ian J. Reynolds
University of Pittsburgh
Pittsburgh, Pennsylvania

A. David Rodrigues
Merck Research Laboratories
West Point, Pennsylvania

Melissa Rogers
University of South Florida
Tampa, Florida

Michael Roguska
Abbott Bioresearch Center
Worcester, Massachusetts

René Rouet
Université de Caen
Boulogne-Billancourt, France

Sylvain Roux
Porsolt and Partners Pharmacology
Boulogne-Billancourt, France

Sylvain Roux
Porsolt and Partners Pharmacology
Le Genest-Saint-Isle, France

Evelyne Sablé
Porsolt and Partners Pharmacology
Le Genest-Saint-Isle, France

Jochen Salfeld
Abbott Bioresearch Center
Worcester, Massachusetts

Joachim Sasse
Shriners Hospital
Tampa, Florida

Alexander Scheer
Serono Pharmaceutical Research Institute
Plan-les-Ouates, Switzerland

R. Scherschlicht
Science Writing
Inzlingen, Germany

Rick G. Schnellmann
Medical University of South Carolina
Charleston, South Carolina

Victoria E.S. Scott
Abbott Laboratories
Abbott Park, Illinois

Terese R. Seifert
Abbott Laboratories
Abbott Park, Illinois

Ze ‘ev Seltzer
University of Toronto
Toronto, Canada

Nigel P. Shankley
Johnson & Johnson Pharmaceutical
La Jolla, California

Thomas K. Shaughnessy
Abbott Laboratories
Abbott Park, Illinois

Jen Sheen
Massachusetts General Hospital and Harvard Medical School
Boston, Massachusetts

Char-Chang Shieh
Abbott Laboratories
Abbott Park, Illinois

Pam A. Silver
Dana-Farber Cancer Institute
Boston, Massachusetts

Peter S. Silverstein
University of Kansas
Lawrence, Kansas

David Skyba
University of Iowa
Iowa City, Iowa

Kathleen A. Sluka
University of Iowa
Iowa City, Iowa

Barbara S. Slusher
Guilford Pharmaceuticals
Baltimore, Maryland

Trevor G. Smart
University College London
London, United Kingdom

Ronald D. Smith
Merck
Whitehouse Station, New Jersey

Dulce Soler
Millennium Pharmaceuticals
Cambridge, Massachusetts

Roger D. Spealman
New England Regional Primate Research Center
Harvard Medical School
Southborough, Massachusetts

Michael Stashko
Abbott Laboratories
Abbott Park, Illinois

Troy Stevens
University of South Alabama College of Medicine
Mobile, Alabama

Jay C. Strum
GlaxoSmithKline
Research Triangle Park, North Carolina

Joan S. Stuart
GlaxoSmithKline
Research Triangle Park, North Carolina

James P. Sullivan
Abbott Laboratories
Abbott Park, Illinois

Jan Svartengren
Biovitrum
Stockholm, Sweden

Philip Thomas
University College London
London, United Kingdom

W. Joseph Thompson
University of South Alabama College of Medicine
Mobile, Alabama

Maharaj K. Ticku
The University of Texas Health Science Center
San Antonio, Texas

Carol W. Tiffany
Guilford Pharmaceuticals
Baltimore, Maryland

Pieter B.M.W.M. Timmermans
Tularik
South San Francisco, California

Keith F. Tipton
Trinity College
Dublin, Ireland

James Trevillyan
Abbott Laboratories
Abbott Park, Illinois

David J. Triggle
The State University of New York
Buffalo, New York

David G. Trist
Glaxo Wellcome S.p.A.
Verona, Italy

Tim van Biesen
Abbott Laboratories
Abbott Park, Illinois

Jan A.M. van der Heyden
Solvay Pharmaceuticals B.V.
Weesp, The Netherlands

Ruud van Oorschot
Solvay Pharmaceuticals B.V.
Weesp, The Netherlands

Olga Valverde
University Pompeu Fabra
Barcelona, Spain

Jeffrey F. Waring
Abbott Laboratories
Abbott Park, Illinois

Simon Watkins
University of Pittsburgh Medical School
Pittsburgh, Pennsylvania

Nikki Watson
Roche Bioscience
Palo Alto, California

Gillian F. Watt
James Black Foundation
London, United Kingdom

Steven J. Weber
Pfizer Global Research & Development
Ann Arbor, Michigan

Craig D. Wegner
Abbott Laboratories
Abbott Park, Illinois

Kristi L. Whiteaker
Abbott Laboratories
Abbott Park, Illinois

Phyllis E. Whiteley
Roche Bioscience
Palo Alto, California

Alan D. Wickenden
Icagen
Durham, North Carolina

Michael Williams
Cephalon
West Chester, Pennsylvania

Ian Williamson
Discovery Biology
Pfizer Central Research
Sandwich, United Kingdom

Rolf T. Windh
Adolor Corporation
Exton, Pennsylvania

Pancras C. Wong
DuPont Merck Pharmaceuticals
Wilmington, Delaware

David F. Woodward
Allergan
Irvine, California

Jerry L. Workman
Pennsylvania State University
University Park, Pennsylvania

Joseph R. Woska, Jr.
Boehringer Ingelheim Pharmaceuticals
Ridgefield, Connecticut

Rolf Zeller
University of Utrecht
The Netherlands

Theo J.J. Zethof
Solvay Pharmaceuticals B.V.
Weesp, The Netherlands

Fang L. Zhang
Schering-Plough Research Institute
Kenilworth, New Jersey

Jie Zhang
Guilford Pharmaceuticals
Baltimore, Maryland

Wei Zheng
Merck
North Wales, Pennsylvania

Anruo Zou
Icagen
Durham, North Carolina