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Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry

Last Update: March 27, 2014
Print ISSN: 1934-9270
Online ISSN: 1934-9289

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What's New in Current Protocols in Nucleic Acid Chemistry
Supplement 56, March 2014

Unit 4.58 Synthesis of 8-Oxoguanosine Phosphoramidite and Its Incorporation into Oligoribonucleotides
         Abstract | Full Text:  HTML   PDF

Unit 5.14 Synthesis of G-N2-(CH2)3-N2-G Trimethylene DNA Interstrand Cross-Links
         Abstract | Full Text:  HTML   PDF

Unit 7.10 Molecular Modeling of Nucleic Acid Structure: Setup and Analysis
         Abstract | Full Text:  HTML   PDF

Unit 9.6 In Vitro Selection Using Modified or Unnatural Nucleotides
         Abstract | Full Text:  HTML   PDF

Unit 14.10 Anti-HIV Nucleoside Phosphonate GS-9148 and Its Prodrug GS-9131: Scale Up of a 2’-F Modified Cyclic Nucleoside Phosphonate and Synthesis of Selected Amidate Prodrugs
         Abstract | Full Text:  HTML   PDF

Published in association with International Society for Nucleosides, Nucleotides & Nucleic Acids (IS3NA), Current Protocols in Nucleic Acid Chemistry is the resource for designing and running successful research projects in the rapidly growing and changing field of nucleic acid, nucleotide, and nucleoside research. Developed by an international group of editors and authors, the methods draw from a unique set of chemistries to synthesize modified nucleic acids, which can be used in structure-function studies, as therapeutic agents, and as tools for molecular biology. It is equally valuable for biotech, pharmaceutical, and academic labs. It is the resource for designing and running successful research projects in the rapidly growing and changing field of nucleic acid, nucleotide, and nucleoside research.

A subscription gives you access to all the content in the collection plus four quarterly issues of new and updated content. Current Protocols in Nucleic Acid Chemistry...

  • draws from a unique set of chemistries to synthesize modified nucleic acids, which can be used in structure-function studies, as therapeutic agents, and as tools for molecular biology
  • covers basic to advanced techniques for the synthesis, modification, purification, analysis, and utilization of nucleic acids, nucleotides, and nucleosides
  • includes growing coverage of therapeutic agents, including anticancer and antiviral compounds

Edited by: Martin Egli (Vanderbilt University); Piet Herdewijn (Rega Institute of Medical Research); Akira Matsuda (Hokkaido University); Yogesh S. Sanghvi (Rasayan, Inc.); Past Editors: Martin Egli (Vanderbilt University); Piet Herdewijn (Rega Institute of Medical Research); Akira Matsuda (Hokkaido University); Yogesh S. Sanghvi (Rasayan, Inc.); Past Editors: Serge L. Beaucage (Bethesda, Maryland); Donald E. Bergstrom (Purdue Univeristy); Gary D. Glick (University of Michigan); Roger A. Jones (Rutgers University)

Developmental Editor: Ann Boyle

See is3na.org for information about the society and the International Roundtable (IRT) meetings.

While the authors, editors, and publisher believe that the specification and usage of reagents, equipment, and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they accept no legal responsibility for any errors or omissions, and make no warranty, express or implied, with respect to material contained herein. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. This is particularly important in regard to new or infrequently employed chemicals or experimental reagents. Moreover, the information presented herein is not a substitute for professional judgment, especially as concerns any applications in a clinical setting or the interpretation of results thereby obtained.