Using the NONCODE Database Resource

Li Xiyuan1, Bu Dechao2, Sun Liang3, Wu Yang4, Fang Shuangsang5, Li Hui5, Luo Haitao5, Luo Chunlong5, Fang Wenzheng5, Chen Runsheng6, Zhao Yi2

1 Beijing Zhongke Jingyun Technology Company Ltd., Medicine. Beijing, 2 Chinese Academy of Sciences, LuoYang Branch of Institute of Computing Technology, Beijing, 3 Wenzhou Medical University, College of Laboratory Medicine and Life Sciences, Department of Laboratory Medicine, Beijing, 4 Chinese Academy of Sciences, Institute of Computing Technology, Bioinformatics Research Group, Advanced Computing Research Laboratory, Beijing, 5 Institute of Computing Technology Chinese Academy of Sciences, Bioinformatics Research Group, Advanced Computing Research Laboratory, Beijing, 6 Institute of Biophysics, Chinese Academy of Sciences, CAS Key Laboratory of RNA Biology, Beijing
Publication Name:  Current Protocols in Bioinformatics
Unit Number:  Unit 12.16
DOI:  10.1002/cpbi.25
Online Posting Date:  June, 2017
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Abstract

NONCODE is a comprehensive database that aims to present the most complete collection and annotation of non‐coding RNAs, especially long non‐coding RNAs (lncRNA genes), and thus NONCODE is essential to modern biological and medical research. Scientists are producing a flood of new data from which new lncRNA genes and lncRNA‐disease relationships are continually being identified. NONCODE assimilates such information from a wide variety of sources including published articles, RNA‐seq data, micro‐array data and databases on genetic variation (dbSNP) and genome‐wide associations (GWAS). NONCODE organizes all this information and makes it freely available to the public via the Internet. The NONCODE protocol provides step‐by‐step instructions on how to browse and search lncRNA information such as sequence, expression, and disease relationships, how to use the tools for functional prediction, species conservation assays, blast analysis, identifier conversion, and, finally, how to submit sequences to identify lncRNA genes. As of Dec 2016, NONCODE has cataloged 487,851 lncRNA genes sequenced from 16 species. © 2017 by John Wiley & Sons, Inc.

Keywords: long non‐coding RNA; NONCODE database; information retrieval; species conservation; bioinformatics; functional annotation

     
 
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Table of Contents

  • Commentary
  • Literature Cited
  • Figures
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Literature Cited

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