Overview of the Cell Cycle

Michele S. Park1, Andrew Koff1

1 Memorial Sloan‐Kettering Cancer Center, New York, New York
Publication Name:  Current Protocols in Cell Biology
Unit Number:  Unit 8.1
DOI:  10.1002/0471143030.cb0801s00
Online Posting Date:  May, 2001
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Abstract

Progression through the cell cycle is regulated by inductive signals from outside the cell and intracellular signal pathways, while the cycle itself is regulated by cyclin‐dependent kinases (CDKs). An understanding of the functions of these molecules is necessary to understand the processes of mitosis, differentiation, senescence, apoptosis, and tumorigenesis. This overview reviews the current state of knowledge for the biology of the cell‐cycle, the CDKs, the role of proteolysis, targets of the cell cycle machinery, and a paradigm of cell cycle analysis.

     
 
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Table of Contents

  • The Biology of the Cell Cycle
  • The Cell Cycle Engine
  • Targets of the Cell Cycle Machinery
  • A Paradigm of Cell Cycle Analysis
  • Literature Cited
  • Figures
  • Tables
     
 
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Materials

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Literature Cited

Literature Cited
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