Overview of Protein Trafficking in the Secretory and Endocytic Pathways

Caroline Enns1

1 Oregon Health Sciences University, Portland, Oregon
Publication Name:  Current Protocols in Cell Biology
Unit Number:  Unit 15.1
DOI:  10.1002/0471143030.cb1501s03
Online Posting Date:  May, 2001
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Abstract

Proteins migrate from the site of their synthesis to intracellular, surface, or extracellular sites depending on their function. This well‐illustrated overview provides an introduction to the pathways of protein trafficking. It includes descriptions of the relevant cellular compartments, modifications associated with the movement of proteins through these compartments, signals used for targeting and translocation, mechanisms for transit between compartments, and methods for sorting proteins.

     
 
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Table of Contents

  • Compartmentalization of Eukaryotic Cells
  • Targeting and Translocation of Proteins into the ER
  • Protein Modifications in the ER
  • ER‐Associated Protein Degradation
  • Transit Between the ER and the Golgi Complex
  • Retention in the ER and Retrieval from the Golgi Complex
  • Carbohydrate Modifications in the Golgi Complex
  • Models of Protein Retention in and Transport Through the Golgi Complex
  • Protein Sorting in Post‐Golgi Compartments
  • Endocytosis
  • Biochemical Analyses of Protein Trafficking
  • Literature Cited
  • Figures
     
 
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Materials

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Literature Cited

Literature Cited
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