Stem Cells: An Overview

Mark Denham1, Brock Conley1, Fredrik Olsson1, Timothy J. Cole1, Richard Mollard1

1 Monash University, Melbourne
Publication Name:  Current Protocols in Cell Biology
Unit Number:  Unit 23.1
DOI:  10.1002/0471143030.cb2301s28
Online Posting Date:  October, 2005
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Stem cells are specialized cells that possess a capacity to undergo self‐renewal while at the same time having the ability to give rise to at least one or more differentiated or mature cell type. They therefore represent a fundamental cornerstone during the life of all vertebrates, playing central roles in the production of new and replacement cells for tissues during development and homeostasis, including repair following disease or injury. This unit is a review of stem cells, their roles in development, and their potentials as therapeutic agents.

Keywords: Embryonic; Adult; Hematopoietic; Mesenchymal; Neural stem cell; Therapy

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Table of Contents

  • The Stem Cell Niche
  • Immortality: Telomerase and Stem Cells
  • The Embryonic Stem Cell as a Pluripotent Stem Cell
  • Multipotent Stem Cells
  • Adult Stem Cells Displaying Unexpected Multipotentiality
  • Stem Cells Stimulate Endogenous Repair
  • Genetic Manipulation of Embryonic Stem Cells
  • Therapeutic Applications of Stem Cells
  • Conclusion
  • Literature Cited
  • Figures
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Literature Cited

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