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Overview of Liquid Handling Instrumentation for High‐Throughput Screening Applications
Publication Name:
Current Protocols in Chemical Biology
Unit Number:
DOI:
10.1002/9780470559277.ch090151
Online Posting Date:
December, 2009
Abstract
Liquid handling in the laboratory has unique challenges specific to the types of research being performed. The devices employed for purposes of performing liquid handling can be broken down into three general categories: bulk reagent dispensers, transfer devices, and plate washers. An overview of these types of liquid handlers, as well as common features and relevance to high-throughput applications, are discussed in this article. Important topics such as sterility, ease of use, cost, and instrument design advantages and disadvantages are also covered. Curr. Protoc. Chem Biol. 1:43-54. © 2009 by John Wiley & Sons, Inc.
Keywords: liquid handling; high throughput screening (HTS); laboratory automation; plate filler; plate washer
Figures
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Figure 1. ThermoFisher Matrix Wellmate peristaltic pump plate filler. -
Figure 2. Agilent (formerly Velocity11) Bravo automated liquid handling platform. Magnifications of the 384- and 96-channel pipetting heads are shown in the right panels. -
Figure 3. V&P Scientific (http://www.vp-scientific.com) floating 0.787-mm diameter 100-nl slotted 384-pin tool. -
Figure 4. BioTek ELx405 Plate Washer with BioStack Microplate Stacker and reagent source bottles. Inset, top right: close-up of aspirating and dispensing pins.
Videos
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