Compound Management: Guidelines for Compound Storage, Provision, and Quality Control

Sue Holland‐Crimmin1, Paul Gosnell1, Chad Quinn1

1 Platform Technology and Sciences, GlaxoSmithKline, Collegeville, Pennsylvania
Publication Name:  Current Protocols in Chemical Biology
Unit Number:   
DOI:  10.1002/9780470559277.ch110095
Online Posting Date:  September, 2011
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The scientific discipline of compound management has developed significantly over the last decade, as witnessed by the large number of conferences dedicated to this topic. The key elements of compound management include (1) the management, storage, and processing of both solids and liquids; (2) compound delivery and interface with key customers; (3) performance of instruments and automation that support these operations; (4) analytical techniques used for quality assurance; and (5) sample informatics, including registration, routing, and compound quality data. This article incorporates guidelines, best practices, and experimental protocols for these key aspects of compound management. Curr. Protoc. Chem. Biol. 3:141‐152 © 2011 by John Wiley & Sons, Inc.

Keywords: adaptive focused acoustics; AFA; compound management; CM; high throughput screening; HTS; quality assurance; QA; volatile solvent transfer; VST

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Table of Contents

  • Introduction
  • Solid Compound Management
  • Compound Solubilization
  • Solution Libraries and DMSO
  • The Importance of Quality
  • Conclusion
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

Literature Cited
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