Laboratory Notebooks and Data Storage

Michael Williams1, Donna Bozyczko‐Coyne1, Bruce Dorsey1, Scott Larsen1

1 Cephalon, Inc., Frazer, Pennsylvania
Publication Name:  Current Protocols Essential Laboratory Techniques
Unit Number:  Appendix 2A
DOI:  10.1002/9780470089941.eta02as00
Online Posting Date:  October, 2008
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Abstract

The laboratory notebook, whether in hardcopy or electronic (ELN) format, represents a true, chronological record of a scientist's bench work, incorporating the primary source of all materials and information related to the design, execution, and outcomes (data) for a specific experiment. The notebook content thus represents a precise, legible record of what was done, why, and by whom. It also describes the outcome of the experiment and how this is related to the initial hypothesis on which performing the experiment was based. As an archive, a laboratory notebook allows others previously unassociated with the work to understand what was done and, if necessary, independently recreate the experiments. A laboratory notebook and its associated records (e.g., computer printouts or HPLC traces) also represent the vital record of the conception date of an invention and its reduction to practice, providing a timely and necessary legal record to support and defend patent applications.

Keywords: laboratory notebook; electronic notebook (ELN); experimentation; intellectual property; patents

     
 
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Table of Contents

  • Hard Copy, Paper Notebooks
  • Electronic Notebooks (ELNS)
  • Patents and Intellectual Property
  • Comments
  • Literature Cited
  • Figures
  • Tables
     
 
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Materials

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Figures

Videos

Literature Cited

   Altman, D.G. and Bland, J.M. 1995. Absence of evidence is not evidence of absence. B.M.J. 311:485.
   Ator, M.A., Mallamo, J.P., and Williams, M. 2006. Overview of drug discovery and development. Curr. Protoc. Pharmacol. 35:9.9.1‐9.9.27. John Wiley & Sons, Hoboken, N.J.
   Elliott, M. 2004. Electronic Laboratory Notebooks, A Foundation for Knowledge Management, 2nd ed. Attrium Research and Consulting, Wilton, Conn.
   Interlandi, J. 2006. An unwelcome discovery. The New York Times Magazine. Oct. 22.
   Kanare, M. 1985. Writing the Laboratory Notebook. American Chemical Society, Washington, D.C.
   Lutz, M. and Kenakin, T. 1999. Quantitative molecular pharmacology and informatics. In Drug Discovery. John Wiley & Sons, Chichester, U.K.
   Neubig, R.R., Spedding, M., Kenakin, T., and Christopoulos, A. 2003. International union of pharmacology committee on receptor nomenclature and drug classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol. Rev. 55:597‐606.
   Taylor, K. 2006. The status of electronic laboratory notebooks for chemistry and biology. Curr. Opin. Drug Disc. Develop. 9:348–353.
   Watling, K.J. 2006. The Sigma‐RBI Handbook of Receptors and Signal Transduction, 5th ed. Sigma‐RBI, Natick, Mass.
   Williams, M. and Rodnight, R. 1977. Protein phosphorylation in nervous tissue: Possible involvement in nervous tissue function and relationship to cyclic nucleotide metabolism. Prog. Neurobiol. 8:183‐250
Internet Resources
  http://www.fda.gov/ora/compliance_ref/bimo/glp/default.htm
  U.S. Food and Drug Administration. Code of Federal Regulations 21 Part 58, FDA Good Laboratory Practices.
  http://www.censa.org
  The Collaborative Electronic Notebook Systems Association (CENSA) Web site.
  http://www.safe‐biopharma.org
  Signatures and authentication for everyone (SAFE). SAFE‐BioPharma Association, New York.
  http://www.scrip‐safe.com
  SCRIP‐SAFE International: Securing documents for business and education.
  http://www.idbs.com/products/abase
  ActiveBase and Oracle software programs are routinely used as part of biological database platforms.
  http://www.oracle.com/index.html
  A software program for data analysis that can integrate and manipulate newly generated data in the context of existing database information.
  http://www.spotfire.com/products/dxp.cfm
  Use this Web site to survey new software programs useful for data analysis that can integrate and manipulate newly generated data in the context of existing database information. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel. A page in a hypothetical notebook prepared by John Hancock and verified by Alfred Nobel.
  http://www.knowledgestorm.com/search/keyword/Biology
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