Pedigree Selection and Information Content

Elizabeth R. Hauser1, Daniel E. Weeks2

1 Duke University Medical Center, Durham, North Carolina, 2 University of Pittsburgh, Pittsburgh, Pennsylvania
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Unit 1.2
DOI:  10.1002/0471142905.hg0102s29
Online Posting Date:  August, 2001
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This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis. It includes methods for determining the power of a dataset to detect genetic loci for both model‐based (lod score) and model‐free (affected sib‐pair, affected‐relative pair) analyses.This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis.

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Table of Contents

  • Introduction
  • Key Concepts
  • Strategic Approach: Pedigree Selection and Evaluation of Pedigree Data for Information Content
  • Commentary
  • Figures
  • Tables
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