Construction of Reference Genetic Maps

Kenneth H. Buetow1

1 Fox Chase Cancer Center, Philadelphia, Pennsylvania
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Unit 1.5
DOI:  10.1002/0471142905.hg0105s01
Online Posting Date:  May, 2001
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Abstract

This unit details the specialized resources and procedures used for constructing reference genetic maps. Construction of such maps in humans represents a subset of the linkage analysis problem. Objectives include the addition of a new locus to an established map, development of a detailed map of loci in a localized area, and construction of de novo maps. Conceptually, the procedures for updating a reference map through the addition of a subset of new loci are similar to those used in establishing linkage for a disease locus. However, construction of new maps of multiple loci is most efficiently accomplished using different family resources that permit the use of accumulated typing resources and alternative, highly efficient statistical methods.

     
 
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Table of Contents

  • Introduction
  • Key Concepts
  • Strategic Approach: Constructing a Reference Map
  • Commentary
  • Literature Cited
     
 
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Materials

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Figures

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Literature Cited

Literature Cited
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