Model‐Free Tests for Genetic Linkage

Christopher I. Amos1, Audrey Schnell2, Wei V. Chen1, Robert C. Elston3

1 University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 2 University of Washington, Seattle, Washington, 3 Case Western University, Cleveland, Ohio
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Unit 1.8
DOI:  10.1002/0471142905.hg0108s75
Online Posting Date:  October, 2012
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This unit covers statistical methods of linkage analysis that do not require the assumption of a detailed genetic model, as is required for standard lod score analysis. The unit has been updated to include the latest methods in sib‐pair analysis, including updates to using the software program SIBPAL as well as the relative‐pair analysis software applications GENEHUNTER, GENEHUNTER PLUS, and Merlin. Curr. Protoc. Hum. Genet. 75:1.8.1‐1.8.32. © 2012 by John Wiley & Sons, Inc.

Keywords: robust linkage tests; pedigree methods; sib pair tests

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Table of Contents

  • Introduction
  • Key Concepts
  • Strategic Approach
  • Commentary
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

Literature Cited
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