Overview of Admixture Mapping

Daniel Shriner1

1 Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Unit 1.23
DOI:  10.1002/cphg.44
Online Posting Date:  July, 2017
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Admixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to Americans who trace ancestry to various combinations of Native Americans, Europeans, and West Africans. Recent developments in admixture mapping include improvements in methods and the reference data needed to make inferences about ancestry, as well as extensions of the mapping approach in the framework of linear mixed models. In this unit, the key concepts of admixture mapping are outlined. Several approaches for inferring local ancestry are described, and strategies for performing admixture mapping depending on the study design are provided. Finally, comparisons and contrasts between linkage analysis, association analysis, and admixture mapping are provided, with an emphasis on integrating admixture mapping and association testing. © 2017 by John Wiley & Sons, Inc.

Keywords: admixture; admixture mapping; ancestry

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Table of Contents

  • Introduction
  • Key Concepts
  • Strategic Approaches
  • Commentary
  • Conclusions
  • Acknowledgments
  • Literature Cited
  • Figures
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Literature Cited

Literature Cited
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