Overview of Model Systems for the Analysis of Human Disease

Joanne Lind1, Christopher Semsarian2

1 Centenary Institute, Sydney, 2 Royal Prince Alfred Hospital, Sydney
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Unit 15.1
DOI:  10.1002/0471142905.hg1501s48
Online Posting Date:  February, 2006
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Abstract

The development of animal models of human disease has been crucial in elucidating normal organ biology and pathogenic mechanisms leading to disease states, and in the development of new therapeutic strategies to modify disease. This unit provides an overview of various animal models used in the study of human disease and the factors that need to be considered when selecting a suitable animal model appropriate for the disease under investigation.

Keywords: Human disease; animal model; disease phenotype; transgenic; gene silencing; knockout

     
 
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