Use of Chicken Models for the Analysis of Human Disease

Jerry B. Dodgson1, Michael N. Romanov1

1 Michigan State University, East Lansing, Michigan
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Unit 15.5
DOI:  10.1002/0471142905.hg1505s40
Online Posting Date:  May, 2004
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The chicken has been a valuable model organism for genetic analysis since early in the last century. This unit provides an overview of the primary strategic approaches through which the chicken is used as a model for human genetics and disease. These approaches are reviewed with key advantages and disadvantages noted for each. In addition, the chicken offers a model system for several human inherited diseases, both single gene‐based and complex traits. This unit briefly describes two such models as examples: autoimmune pathology causing Hashimoto's thyroiditis and sex‐linked dwarfism.

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Table of Contents

  • Strategic Approaches
  • Examples of Chicken Models of Human Disease
  • Concluding Remarks
  • Literature Cited
  • Tables
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Key References
   Brown, et al., 2003. See above.
  Reviews the value of the chicken as a model organism, especially in developmental biology.
   Burt, 2002. See above.
  A compilation of the mammalian‐chicken comparative map and a discussion of chromosomal evolution.
   Muir and Aggrey, 2003. See above.
  Overview of poultry genetics with an emphasis on applications to agriculture and industry.
   Schmid et al., 2000. See above.
  Reviews the status of the linkage map and related chicken genomics research.
   Thomas et al., 2003. See above.
  Describes the use of chicken DNA sequence information and that of other species for the identification of exons and regulatory regions in sequenced vertebrate genomes.
Internet Resources
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