Human and Mouse Gene Nomenclature

Hester Wain1, Sue Povey1, Lois Maltais2

1 University College London, London, 2 The Jackson Laboratory, Bar Harbor, Maine
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Appendix 1C
DOI:  10.1002/0471142905.hga01cs35
Online Posting Date:  February, 2003
GO TO THE FULL TEXT: PDF or HTML at Wiley Online Library


Standard genetic nomenclature is necessary to help researchers, clinicians, and the public to access data on their genes of interest, and to communicate in a globally understood language of approved gene symbols. In both human and mouse, one unique symbol (acronym/abbreviation) and one name are assigned for each gene. Co‚Äźordination between human and mouse gene nomenclature is a successful endeavor, due in part to the historical interaction between the two nomenclature committee groups. This interaction grew out of the Human Gene Mapping (HGM) Workshops. This appendix discusses development and organization of gene nomenclature, how to find a gene and how to name a new gene.

PDF or HTML at Wiley Online Library

Table of Contents

  • Development of Standard Nomenclature
  • Current Organization of Nomenclature
  • Global Symbols
  • How to Find the Name of a Published Gene
  • Why Name a New Gene?
  • How to Obtain a New Gene Name
  • Summary of Guidelines for Naming New Genes
  • After a New Symbol is Proposed
  • Problems Which may Arise
  • Once the Symbol is Approved
  • Figures
PDF or HTML at Wiley Online Library


PDF or HTML at Wiley Online Library



Literature Cited

Literature Cited
   Blake, J.A., Davisson, M.T., Eppig, J.T., Maltais, L.J., Povey, S., White, J.A., and Womack, J.E. 1997. A report on the International Nomenclature Workshop held in May 1997 at The Jackson Laboratory. Bar Harbor, Maine. Genomics 45:464‐468.
   Dunn, L.C., Gruneberg, H., and Snell, G.D. 1940. Report of the committee on mouse genetics nomenclature. H. Hered. 31:505‐506.
   Green, M.C. 1981. Genetic Variants and Strains of the Laboratory Mouse, (M.C. Green, ed.), 1st Edition. Gustav Fischer Verlag, Stuttgart, Germany.
   Lyon, M.F., Davisson, M.T., and Peters, J. 1997. Standardized mouse genetic nomenclature: Past history and future perspectives. Mouse Genome 95:840‐843.
   Maltais, L.J. and Jackson, I. 1999. Comment on: Sequencing challenge. Nature 402:347.
   Maltais, L.J., Blake, J.A., Chu, T., Lutz, C.M., Eppig, J.T., and Jackson, I. 2002. Rules and guidelines for mouse gene, allele, and mutation nomenclature: A condensed version. Genomics 79:471‐74.
   Povey, S., Lovering, R., Bruford, E., Wright, M., Lush, M., and Wain, H.M. 2001. The HUGO Gene Nomenclature Committee (HGNC). Nomenclature Recommendations. Human Genetics 106:678‐680.
   Shows, T.B., et al. 1979. International system for human gene nomenclature (1979) ISGN (1979). Cytogenet. Cell Genet. 25:96‐116.
   Wain, H.M., Lush, M., Ducluzeau, F., and Povey, S. 2002. Genew: The Human Nomenclature Database. Nuc. Acids Res. 30:169‐171.
   Wain, H.M., Bruford, E.A., Lovering, R.C., Lush, M.J., Wright, M.W., and Povey, S. 2002. Guidelines for human gene nomenclature. Genomics 79:464‐70.
   White, J.A., et al. 1997. Guidelines for human gene nomenclature. Genomics 45:468‐471.
   White, J., Maltais, L., and Nebert, D. 1998. Networking nomenclature. Nat. Genet. 18:209.
   White, J.A., Apweiler, R., Blake, J.A., Eppig, J.T., Maltais, L.J., and Povey, S. 1999. Report of the Second International Nomenclature Workshop. Genomics 62:320‐323.
Internet Resources
PDF or HTML at Wiley Online Library