ISCN Standard Idiograms

Rhona R. Schreck1, Christine M. Distèche2, David Adler2

1 Cedars‐Sinai Medical Center, Los Angeles, California, 2 University of Washington, Seattle, Washington
Publication Name:  Current Protocols in Human Genetics
Unit Number:  Appendix 4B
DOI:  10.1002/0471142905.hga04bs18
Online Posting Date:  May, 2001
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Abstract

Chromosome banding is used mainly to identify both normal and rearranged chromosomes, to define chromosome breakpoints, and to describe the specific location of DNA sequences on chromosomes. A nomenclature has been developed to standardize the identification of chromosomes and the naming of chromosome bands. The system currently in use is An International System for Human Cytogenetic Nomenclature, referred to as “ISCN 1995.” It is the report of the standing committee on human cytogenetic nomenclature edited by Felix Mitelman. The report includes a chromosome band nomenclature, as well as standard idiograms, which are “diagrammatic representations of a karyotype, which may be based on measurements of the chromosomes” (ISCN 1995). The idiograms presented here, with the permission of S. Karger and Cytogenetics and Cell Genetics, are drawings of G‐banded chromosomes with band numbers indicated. Heterochromatic regions, which contain classes of repetitive DNA and can show individual differences in size, are indicated by patterned areas.

     
 
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Table of Contents

  • Idiograms and Band Resolutions
  • Chromosome Band Nomenclature
  • Idiogram Figures
  • Literature Cited
  • Figures
     
 
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Materials

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Figures

Videos

Literature Cited

Literature Cited
   Francke, U. 1981. High resolution ideograms of trypsin‐Giemsa banded human chromosomes. Cytogenet. Cell Genet. 31:24‐32.
   Francke, U. 1994a. Digitized and differentially shaded human chromosome ideograms for genomic applications. Cytogenet. Cell Genet. 65:206‐219.
   Francke, U. 1994b. Digitized Human Chromosome Ideograms Diskette (for use on Macintosh or PC with Adobe Illustrator; H.P. Klinger, ed.). S. Karger, Basel, Switzerland, and Farmington, Conn.
   ISCN. 1981. An International System for Human Cytogenetic Nomenclature—High‐Resolution Banding (D.G. Harnden, J.E. Lindsten, K. Buckton, and H.P. Klinger, eds.). S. Karger, Basel, Switzerland.
   ISCN. 1995. An International System for Human Cytogenetic Nomenclature (F. Mitelman, ed.). S. Karger, Basel.
   Magenis, E. and Barton, S.J. 1987. Delineation of human prometaphase paracentromeric regions using sequential GTG‐ and C‐banding. Cytogenet. Cell Genet. 45:132‐140.
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