Animal Health Assurance

John Donovan1, Patricia Brown2

1 Wyeth Research, Collegeville, Pennsylvania, 2 National Institutes of Health, Bethesda, Maryland
Publication Name:  Current Protocols in Immunology
Unit Number:  Unit 1.1
DOI:  10.1002/0471142735.im0101s76
Online Posting Date:  February, 2007
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Abstract

A program to ensure the health of laboratory animals and to provide a stable environment for their maintenance is necessary to reduce unwanted variables or complicating factors in experimentation. To ensure animal health throughout a research study, the animals involved should be procured in good health, monitored for continued health status, and protected from pathogenic organisms through testing of any biological materials. This unit addresses all three of these health management practices. Essential in support of these practices is a diagnostic laboratory capable of testing for rodent and rabbit pathogens.

Keywords: animal husbandry; commercial sources of animals; monitoring animal health; animal facilities; specific pathogen free facilities; pathogenic microorganisms of rodents and rabbits

     
 
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Table of Contents

  • Quarantine and Stabilization
  • Health Monitoring
  • Testing of Biological Material
  • DISCLAIMER
  • Literature Cited
  • Tables
     
 
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Materials

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Figures

Videos

Literature Cited

   Institute for Laboratory Animal Research (ILAR). 2006. Guidelines for the Humane Transportation of Research Animals. The National Academies Press, Washington, D.C.
   Percy, D.H. and Barthold, S.W. 2001. Pathology of Laboratory Rodents and Rabbits, 2nd ed. Iowa State University Press, Ames, Iowa.
Key References
   Fox, J.G., Anderson, L.C., Loew, F.M., and Quimby, F.W. (eds.) 2002. Laboratory Animal Medicine, 2nd ed. Academic Press. San Diego.
  The American College of Laboratory Animal Medicine (ACLAM) series of texts listed above provides excellent information on the complications to research resulting from intercurrent infections.
   Fox, J.G., Barthold, S., Davisson, M., Newcomer, C., Quimby, F., and Smith, A. (eds.) 2006. The Mouse in Biomedical Research: Volume 2, Diseases, 2nd ed. ACLAM Series. Academic Press, San Diego.
   Manning, P.J., Ringler, D.H., and Newcomer, C.E. (eds.) 1994. The Biology of the Laboratory Rabbit, 2nd ed. ACLAM Series. Academic Press, San Diego.
   Percy and Barthold, 2001. See above.
   Reuter, J.D. and Dysko, R.C. 2003. Quality asurance/surveillance monitoring programs for rodent colonies. In Laboratory Animal Medicine and Management (J.D. Reuter and M.A. Suckow, eds.) pp. 1‐13. International Veterinary Information Service, Ithaca, New York.
   Suckow, M.A., Weisbroth, S.H. and Franklin, C.L. (eds.) 2005. The Laboratory Rat, 2nd ed. ACLAM Series. Academic Press, San Diego.
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