Key Molecules Involved in Receptor‐Mediated Lymphocyte Activation

John J. O'Shea1, James A. Johnston2, John Kehrl3, Gary Koretzky4, Lawrence E. Samelson5

1 National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, 2 DNAX, Palo Alto, California, 3 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, 4 University of Iowa College of Medicine, Iowa City, Iowa, 5 National Institute of Child Health and Human Development, Bethesda, Maryland
Publication Name:  Current Protocols in Immunology
Unit Number:  Unit 11.9A
DOI:  10.1002/0471142735.im1109as44
Online Posting Date:  November, 2001
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This unit, along with Unit 11.9B, provides a summary of our current knowledge about various signaling pathways critical to the function of immune cells. Here, our understanding of T cell receptor (TCR)‐ and B cell receptor (BCR)‐mediated signaling is summarized. A schematic representation of immunologically relevant cytokine receptors and the Janus Family Kinases (JAKs) that is activated through these receptors is provided, along with details about molecules involved in interleukin 2 mediated signal transduction.

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Table of Contents

  • Introduction
  • Signaling Molecules
  • T Cell Receptor (TCR) Signal Transduction
  • B Cell Receptor (BCR) Signal Transduction
  • Signaling Via the Interleukin 2 Receptor (IL‐2R) and Related Receptors
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

Literature Cited
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