TRAF‐Mediated TNFR‐Family Signaling

Hyunil Ha1, Daehee Han1, Yongwon Choi1

1 University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Publication Name:  Current Protocols in Immunology
Unit Number:  Unit 11.9D
DOI:  10.1002/0471142735.im1109ds87
Online Posting Date:  November, 2009
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The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell‐bound and secreted proteins that regulate numerous cellular processes. In particular, TNF‐family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor‐associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF‐interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF‐knockout mice. Curr. Protoc. Immunol. 87:11.9D.1‐11.9D.19. © 2009 by John Wiley & Sons, Inc.

Keywords: TNF family; TNFR family; IL‐1R/TLR; TRAF proteins; signal transduction; inflammation

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Table of Contents

  • TNF and TNFR Superfamilies
  • Activated Receptors
  • TRAF Proteins
  • Structural Features of TRAF Proteins
  • TRAF‐Interacting Proteins
  • Signaling Pathways Activated by TRAF Proteins
  • TRAF Knockout Mice
  • Literature Cited
  • Figures
  • Tables
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PDF or HTML at Wiley Online Library



Literature Cited

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