The Immune Response to Tumors

Michael Dougan1, Glenn Dranoff1

1 Department of Medical Oncology and Cancer Vaccine Center, Dana‐Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
Publication Name:  Current Protocols in Immunology
Unit Number:  Unit 20.11
DOI:  10.1002/0471142735.im2011s85
Online Posting Date:  April, 2009
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The immune response to tumors is complex. Cells of the immune system can inhibit tumor growth and progression through the recognition and rejection of malignant cells, a process referred to as immunoediting. Yet, immune responses can also promote tumor cell growth, survival, and angiogenesis through the induction of oncogenic inflammation. Immunodeficiency can predispose to the development of spontaneous and virally induced cancer, and established tumors often generate immunosuppressive microenvironments that can block productive antitumor immunity, serving as a substantial barrier to effective immune therapy. Through a deeper understanding of the complicated relationship between tumors and the immune system, tumor immunology strives to harness the immune system to generate protective antitumor responses in patients. Curr. Protoc. Immunol. 85:20.11.1‐20.11.4. © 2009 by John Wiley & Sons, Inc.

Keywords: cancer; immunoediting; immunotherapy; immunosuppression; inflammation; antitumor immunity

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Table of Contents

  • Introduction
  • Immunoediting and Spontaneous Antitumor Immunity
  • Immunosuppression in the Tumor Microenvironment
  • Tumor Promotion by Chronic Inflammation
  • Therapeutic Induction of Antitumor Immunity
  • Literature Cited
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Literature Cited

Literature Cited
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