Commonly Used Mouse Strains

Ada M. Kruisbeek1

1 Netherlands Cancer Institute, Amsterdam, The Netherlands
Publication Name:  Current Protocols in Immunology
Unit Number:  Appendix 1C
DOI:  10.1002/0471142735.ima01cs17
Online Posting Date:  May, 2001
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Abstract

This appendix lists commonly used mouse strains and selected cell‐surface molecules expressed by these strains. H‐2 is the gene locus residing on chromosome 17 of the mouse which encodes major histocompatibility proteins. Only those H‐2 loci involved in immunologic interactions frequently cited in this manual are listed here‐‐i.e., Aa‐, Ab‐, Ea‐, and Eb‐‐region‐encoded MHC class II molecules, and K‐and D‐region‐encoded MHC class I molecules. In addition to H‐2 loci, others are listed that encode immunologically important proteins. Congenic strains listed in this appendix represent inbred strains that were derived from their origin (BALB/c, C57Bl/10, and C3H) by selective matings, such that they differ from that originating strain at only one independently segregating genetic locus. The locus of choice in these cases was H‐2; thus, these strains differ from their strain of origin only in their H‐2 complex, but not in any other loci. During the production of the congenic lines, several strains were derived that had undergone intra‐H‐2 recombination events. These strains are listed here and have been invaluable in defining the major roles of various MHC glycoproteins.

     
 
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Table of Contents

  • Commonly Used Mouse Strains
  • Literature Cited
  • Tables
     
 
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Materials

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Literature Cited

Literature Cited
   Hansen, T.H. and Sachs, D.H. 1989. The major histocompatibility complex. In Fundamentals of Immunology, 2nd ed. (W.E. Paul, ed.), pp.445‐488. Raven Press, New York.
   Janeway, C.C. 1991. kMls: Makes a little sense. Nature 349:459‐460.
   Klein, J. 1986. Immunology: The Science of Self‐Nonself Discrimination. John Wiley & Sons, New York.
   Klein, J., Bontrop, R.E., Dawkins, R.L., Erlich, H.A., Gyllensten, U.B., Heise, E.R., Jones, P.P., Parham, P., Wakeland, E.K., and Watkins, D.I. 1990. Nomenclature for the major histocompatibility complexes of different species: A proposal. Immunogenetics 31:217‐219.
   Morse, H.C., Shen, F‐W., and Hammerling, U. 1987. Genetic nomenclature for loci controlling mouse lymphocyte antigens. Immunogenetics 25:71‐78.
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