Listing, Location, Binding Motifs, and Expression of Nonclassical Class I and Related Genes and Molecules

James Forman1, Kirsten Fischer Lindahl2

1 University of Texas Southwestern Medical Center, Dallas, Texas, 2 Netherlands Cancer Institute
Publication Name:  Current Protocols in Immunology
Unit Number:  Appendix 1M
DOI:  10.1002/0471142735.ima01ms49
Online Posting Date:  August, 2002
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Abstract

The tables presented in this appendix list nonclassical class I or related genes/molecules arranged by the chromosomal region where they are encoded. This includes genes that fall into the Ib region of the murine major histocompatibility complex (MHC) which includes H2‐Q, ‐T, and ‐M, as well as CD1, which lies outside the MHC region. A final table includes genes/molecules that are encoded in diverse regions. They are included in this section because they are either class I related in that their heavy chain is related to classical class I and/or they are associated with ion given is for the C57BL/6 (B6) strain unless otherwise noted.

     
 
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Table of Contents

  • Listing, Location, Binding Motifs, and Expression of Nonclassical Class I and Related Genes and Molecules
  • Literature Cited
  • Tables
     
 
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Literature Cited

Literature Cited
   Aldrich, C.J., DeCloux, A., Woods, A.S., Cotter, R.J., Soloski, M.J., and Forman, J. 1994. Identification of a tap‐dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen. Cell 79:649‐658.
   Angenieux, C., Salamero, J., Fricker, D., Cazenave, J.P., Goud, B., Hanau, D., and de La, S.H. 2000. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J. Biol Chem. 275:37757‐37764.
   Arepalli, S.R., Jones, E.P., Howcroft, T.K., Carlo, I., Wang, C., Lindahl, K.F., Singer, D.S., and Rudikoff, S. 1998. Characterization of two class I genes from the H2‐M region: Evidence for a new subfamily. Immunogenetics 47:264‐271.
   Bahram, S. 2000. MIC genes: From genetics to biology. Adv. Immunol. 76:1‐60.
   Beckman, E.M., Porcelli, S.A., Morita, C.T., Behar, S.M., Furlong, S.T., and Brenner, M.B. 1994. Recognition of a lipid antigen by CD1‐restricted alpha beta+ T cells. Nature 372:691‐694.
   Beckman, E.M., Melian, A., Behar, S.M., Sieling, P.A., Chatterjee, D., Furlong, S.T., Matsumoto, R., Rosat, J.P., Modlin, R.L., and Porcelli, S.A. 1996. CD1c restricts responses of mycobacteria‐specific T cells. Evidence for antigen presentation by a second member of the human CD1 family. J. Immunol. 157:2795‐2803.
   Benlagha, K. and Bendelac, A. 2000. CD1d‐restricted mouse V alpha 14 and human V alpha 24 T cells: Lymphocytes of innate immunity. Semin. Immunol. 12:537‐542.
   Blumberg, R.S., Terhorst, C., Bleicher, P., McDermott, F.V., Allan, C.H., Landau, S.B., Trier, J.S., and Balk, S.P. 1991. Expression of a nonpolymorphic MHC class I‐like molecule, CD1D, by human intestinal epithelial cells. J. Immunol. 147:2518‐2524.
   Borvak, J., Richardson, J., Medesan, C., Antohe, F., Radu, C., Simionescu, M., Ghetie, V., and Ward, E.S. 1998. Functional expression of the MHC class I‐related receptor, FcRn, in endothelial cells of mice. Int. Immunol. 10:1289‐1298.
   Braud, V., Jones, E.Y., and McMichael, A. 1997. The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9. Eur. J. Immunol. 27:1164‐1169.
   Braud, V.M., Allan, D.S., O'Callaghan, C.A., Soderstrom, K., D'Andrea, A., Ogg, G.S., Lazetic, S., Young, N.T., Bell, J.I., Phillips, J.H., Lanier, L.L., and McMichael, A.J. 1998. HLA‐E binds to natural killer cell receptors CD94/NKG2A, B and C [see comments]. Nature 391:795‐799.
   Brorson, K.A., Hunt, S.W. III, Hunkapiller, T., Sun, Y.H., Cheroutre, H., Nickerson, D.A., and Hood, L. 1989a. Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse. J. Exp. Med. 170:1837‐1858.
   Brorson, K.A., Richards, S., Hunt, S.W., Cheroutre, H., Lindahl, K.F., and Hood, L. 1989b. Analysis of a new class I gene mapping to the Hmt region of the mouse. Immunogenetics 30:273‐283.
   Brossay, L., Jullien, D., Cardell, S., Sydora, B.C., Burdin, N., Modlin, R.L., and Kronenberg, M. 1997. Mouse CD1 is mainly expressed on hemopoietic‐derived cells. J. Immunol. 159:1216‐1224.
   Brossay, L., Burdin, N., Tangri, S., and Kronenberg, M. 1998a. Antigen‐presenting function of mouse CD1: One molecule with two different kinds of antigenic ligands. Immunol. Rev. 163:139‐150.
   Brossay, L., Naidenko, O., Burdin, N., Matsuda, J., Sakai, T., and Kronenberg, M. 1998b. Structural requirements for galactosylceramide recognition by CD1‐ restricted NK T cells. J. Immunol. 161:5124‐5128.
   Brown, G.D., Choi, Y., Egan, G., and Meruelo, D. 1988. Extension of the H‐ 2 TLb molecular map. Isolation and characterization of T13, T14, and T15 from the C57BL/6 mouse. Immunogenetics 27:239‐251.
   Calabi, F. and Milstein, C. 1986. A novel family of human major histocompatibility complex‐related genes not mapping to chromosome 6. Nature 323:540‐543.
   Calabi, F., Jarvis, J.M., Martin, L., and Milstein, C. 1989. Two classes of CD1 genes. Eur. J. Immunol. 19:285‐292.
   Castano, A.R., Tangri, S., Miller, J.E., Holcombe, H.R., Jackson, M.R., Huse, W.D., Kronenberg, M., and Peterson, P.A. 1995. Peptide binding and presentation by mouse CD1. Science 269:223‐226.
   Caux, C., Dezutter‐Dambuyant, C., Schmitt, D., and Banchereau, J. 1992. GM‐CSF and TNF‐alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258‐261.
   Cerwenka, A., Bakker, A.B., McClanahan, T., Wagner, J., Wu, J., Phillips, J.H., and Lanier, L.L. 2000. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12:721‐727.
   Chen, Y.H., Wang, B., Chun, T., Zhao, L., Cardell, S., Behar, S.M., Brenner, M.B., and Wang, C.R. 1999. Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1‐deficient mice. J. Immunol. 162:4560‐4566.
   Chun, T., Serbina, N.V., Nolt, D., Wang, B., Chiu, N.M., Flynn, J.L., and Wang, C.R. 2001. Induction of M3‐restricted cytotoxic T lymphocyte responses by N‐formylated peptides derived from mycobacterium tuberculosis. J. Exp. Med. 193:1213‐1220.
   Colonna, M., Navarro, F., Bellon, T., Llano, M., Garcia, P., Samaridis, J., Angman, L., Cella, M., and Lopez‐Botet, M. 1997. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809‐1818.
   Cosman, D., Kress, M., Khoury, G., and Jay, G. 1982. Tissue‐specific expression of an unusual H‐2 (class I)‐related gene. Proc. Natl. Acad. Sci. U.S.A. 79:4947‐4951.
   Cosman, D., Mullberg, J., Sutherland, C.L., Chin, W., Armitage, R., Fanslow, W., Kubin, M., and Chalupny, N.J. 2001. ULBPs, novel MHC class I‐related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14:123‐133.
   Crew, M.D., Bates, L.M., and Douglass, C.A. 1999. Genomic organization and sequence of the H2‐T24 gene. Immunogenetics 49:707‐711.
   Crowley, M.P., Fahrer, A.M., Baumgarth, N., Hampl, J., Gutgemann, I., Teyton, L., and Chien, Y. 2000. A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule. Science 287:314‐316.
   Diefenbach, A., Jamieson, A.M., Liu, S.D., Shastri, N., and Raulet, D.H. 2000. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1:119‐126.
   Eghtesady, P., Brorson, K.A., Cheroutre, H., Tigelaar, R.E., Hood, L., and Kronenberg, M. 1992. Expression of mouse Tla region class I genes in tissues enriched for gamma delta cells. Immunogenetics 36:377‐388.
   Elliott, E., Rathbun, D., Ramsingh, A., Garberi, J., and Flaherty, L. 1989. Genetics and expression of the Q6 and Q8 genes. An LTR‐like sequence in the 3' untranslated region. Immunogenetics 29:371‐379.
   Fahrner, K., Hogan, B.L., and Flavell, R.A. 1987. Transcription of H‐2 and Qa genes in embryonic and adult mice. EMBO J. 6:1265‐1271.
   Fisher, D.A., Pecht, M., and Hood, L. 1989. DNA sequence of a class I pseudogene from the Tla region of the murine MHC: Recombination at a B2 alu repetitive sequence. J. Mol. Evol. 28:306‐312.
   Flaherty, L., Elliott, E., Tine, J.A., Walsh, A.C., and Waters, J.B. 1990. Immunogenetics of the Q and TL regions of the mouse. Crit Rev. Immunol. 10:131‐175.
   Ghetie, V. and Ward, E.S. 2000. Multiple roles for the major histocompatibility complex class I‐ related receptor FcRn. Annu. Rev. Immunol. 18:739‐766.
   Groh, V., Bahram, S., Bauer, S., Herman, A., Beauchamp, M., and Spies, T. 1996. Cell stress‐regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 93:12445‐12450.
   Groh, V., Rhinehart, R., Randolph‐Habecker, J., Topp, M.S., Riddell, S.R., and Spies, T. 2001. Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus‐infected cells. Nat. Immunol. 2:255‐260.
   Hashimoto, K., Hirai, M., and Kurosawa, Y. 1995. A gene outside the human MHC related to classical HLA class I genes. Science 269:693‐695.
   Hershberg, R., Eghtesady, P., Sydora, B., Brorson, K., Cheroutre, H., Modlin, R., and Kronenberg, M. 1990. Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proc. Natl. Acad. Sci. U.S.A. 87:9727‐9731.
   Holcombe, H.R., Castano, A.R., Cheroutre, H., Teitell, M., Maher, J.K., Peterson, P.A., and Kronenberg, M. 1995. Nonclassical behavior of the thymus leukemia antigen: Peptide transporter‐independent expression of a nonclassical class I molecule. J. Exp. Med. 181:1433‐1443.
   Ito, K., Van Kaer, L., Bonneville, M., Hsu, S., Murphy, D.B., and Tonegawa, S. 1990. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell 62:549‐561.
   Joyce, S., Tabaczewski, P., Angeletti, R.H., Nathenson, S.G., and Stroynowski, I. 1994. A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self‐peptides. J. Exp. Med. 179:579‐588.
   Joyce, S., Woods, A.S., Yewdell, J.W., Bennink, J.R., De Silva, A.D., Boesteanu, A., Balk, S.P., Cotter, R.J., and Brutkiewicz, R.R. 1998. Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol. Science 279:1541‐1544.
   Kaufmann, S.H., Emoto, M., Szalay, G., Barsig, J., and Flesch, I.E. 1997. Interleukin‐4 and listeriosis. Immunol. Rev. 158:95‐105.
   Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., Koseki, H., and Taniguchi, M. 1997. CD1d‐restricted and TCR‐mediated activation of valpha14 NKT cells by glycosylceramides. Science 278:1626‐1629.
   Kerksiek, K.M., Busch, D.H., Pilip, I.M., Allen, S.E., and Pamer, E.G. 1999. H2‐M3‐restricted T cells in bacterial infection: Rapid primary but diminished memory responses. J. Exp. Med. 190:195‐204.
   Klein, J., Benoist, C., David, C.S., Demant, P., Lindahl, K.F., Flaherty, L., Flavell, R.A., Hammerling, U., Hood, L.E., and Hunt, S.W.III. 1990. Revised nomenclature of mouse H‐2 genes. Immunogenetics 32:147‐149.
   Kraft, J.R., Vance, R.E., Pohl, J., Martin, A.M., Raulet, D.H., and Jensen, P.E. 2000. Analysis of Qa‐1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa‐1‐peptide complexes. J. Exp. Med. 192:613‐624.
   Kronenberg, M., Brossay, L., Kurepa, Z., and Forman, J. 1999. Conserved lipid and peptide presentation functions of nonclassical class I molecules. Immunol. Today 20:515‐521.
   Le Bouteiller, P. and Solier, C. 2001. Is antigen presentation the primary function of HLA‐G? Microbes. Infect. 3:323‐332.
   Lee, N., Malacko, A.R., Ishitani, A., Chen, M.C., Bajorath, J., Marquardt, H., and Geraghty, D.E. 1995. The membrane‐bound and soluble forms of HLA‐G bind identical sets of endogenous peptides but differ with respect to TAP association. Immunity 3:591‐600.
   Lenz, L.L. and Bevan, M.J. 1997. CTL responses to H2‐M3‐restricted Listeria epitopes. Immunol. Rev. 158:115‐121.
   Lepin, E.J., Bastin, J.M., Allan, D.S., Roncador, G., Braud, V.M., Mason, D.Y., van der Merwe, P.A., McMichael, A.J., Bell, J.I., Powis, S.H., and O'Callaghan, C.A. 2000. Functional characterization of HLA‐F and binding of HLA‐F tetramers to ILT2 and ILT4 receptors. Eur. J. Immunol. 30:3552‐3561.
   Lindahl, K.F., Byers, D.E., Dabhi, V.M., Hovik, R., Jones, E.P., Smith, G.P., Wang, C.R., Xiao, H., and Yoshino, M. 1997. H2‐M3, a full‐service class Ib histocompatibility antigen. Annu. Rev. Immunol. 15:851‐879.
   Malarkannan, S., Shih, P.P., Eden, P.A., Horng, T., Zuberi, A.R., Christianson, G., Roopenian, D., and Shastri, N. 1998. The molecular and functional characterization of a dominant minor H antigen, H60. J. Immunol. 161:3501‐3509.
   Moody, D.B., Reinhold, B.B., Guy, M.R., Beckman, E.M., Frederique, D.E., Furlong, S.T., Ye, S., Reinhold, V.N., Sieling, P.A., Modlin, R.L., Besra, G.S., and Porcelli, S.A. 1997. Structural requirements for glycolipid antigen recognition by CD1b‐ restricted T cells. Science 278:283‐286.
   Moody, D.B., Ulrichs, T., Muhlecker, W., Young, D.C., Gurcha, S.S., Grant, E., Rosat, J.P., Brenner, M.B., Costello, C.E., Besra, G.S., and Porcelli, S.A. 2000. CD1c‐mediated T‐cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404:884‐888.
   Nakayama, K., Tokito, S., Jaulin, C., Delarbre, C., Kourilsky, P., Nakauchi, H., and Gachelin, G. 1990. Comparative structure of two duplicated T1a class I genes (T10c and 37) of the murine H‐2d MHC. Implications on the evolution of the T1a region. J. Immunol. 144:2400‐2408.
   Ohteki, T., Fukao, T., Suzue, K., Maki, C., Ito, M., Nakamura, M., and Koyasu, S. 1999. Interleukin 12‐dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J. Exp. Med. 189:1981‐1986.
   Porcelli, S., Morita, C.T., and Brenner, M.B. 1992. CD1b restricts the response of human CD4‐8‐ T lymphocytes to a microbial antigen. Nature 360:593‐597.
   Porcelli, S.A. and Modlin, R.L. 1999. The CD1 system: Antigen‐presenting molecules for T cell recognition of lipids and glycolipids. Annu. Rev. Immunol. 17:297‐329.
   Rajagopalan, S. and Long, E.O. 1999. A human histocompatibility leukocyte antigen (HLA)‐G‐specific receptor expressed on all natural killer cells. J. Exp. Med. 189:1093‐1100.
   Riegert, P., Wanner, V., and Bahram, S. 1998. Genomics, isoforms, expression, and phylogeny of the MHC class I‐ related MR1 gene. J. Immunol. 161:4066‐4077.
   Robinson, P.J. 1985. Qb‐1, a new class I polypeptide encoded by the Qa region of the mouse H‐ 2 complex. Immunogenetics 22:285‐289.
   Rosat, J.P., Grant, E.P., Beckman, E.M., Dascher, C.C., Sieling, P.A., Frederique, D., Modlin, R.L., Porcelli, S.A., Furlong, S.T., and Brenner, M.B. 1999. CD1‐restricted microbial lipid antigen‐specific recognition found in the CD8+ alpha beta T cell pool. J. Immunol. 162:366‐371.
   Sanchez, L.M., Vizoso, F., Diez‐Itza, I., and Lopez‐Otin, C. 1992. Identification of the major protein components in breast secretions from women with benign and malignant breast diseases. Cancer Res. 52:95‐100.
   Sanchez, L.M., Chirino, A.J., and Bjorkman, P. 1999. Crystal structure of human ZAG, a fat‐depleting factor related to MHC molecules. Science 283:1914‐1919.
   Schofield, L., McConville, M.J., Hansen, D., Campbell, A.S., Fraser‐Reid, B., Grusby, M.J., and Tachado, S.D. 1999. CD1d‐restricted immunoglobulin G formation to GPI‐anchored antigens mediated by NKT cells. Science 283:225‐229.
   Seaman, M.S., Perarnau, B., Lindahl, K.F., Lemonnier, F.A., and Forman, J. 1999. Response to Listeria monocytogenes in mice lacking MHC class Ia molecules. J. Immunol. 162:5429‐5436.
   Sharma, P., Joyce, S., Chorney, K.A., Griffith, J.W., Bonneau, R.H., Wilson, F.D., Johnson, C.A., Flavell, R.A., and Chorney, M.J. 1996. Thymus‐leukemia antigen interacts with T cells and self‐peptides. J. Immunol. 156:987‐996.
   Sieling, P.A., Chatterjee, D., Porcelli, S.A., Prigozy, T.I., Mazzaccaro, R.J., Soriano, T., Bloom, B.R., Brenner, M.B., Kronenberg, M., and Brennan, P.J. 1995. CD1‐restricted T cell recognition of microbial lipoglycan antigens. Science 269:227‐230.
   Singer, D.S., Hare, J., Golding, H., Flaherty, L., and Rudikoff, S. 1988. Characterization of a new subfamily of class I genes in the H‐2 complex of the mouse. Immunogenetics 28:13‐21.
   Sipes, S.L., Medaglia, M.V., Stabley, D.L., DeBruyn, C.S., Alden, M.S., Catenacci, V., and Landel, C.P. 1996. A new major histocompatibility complex class I b gene expressed in the mouse blastocyst and placenta. Immunogenetics 45:108‐120.
   Stroynowski, I. 1995. Tissue‐specific, peptide‐binding transplantation antigens: Lessons from the Qa‐2 system. Immunol. Rev. 147:91‐108.
   Sugita, M., van Der, W.N., Rogers, R.A., Peters, P.J., and Brenner, M.B. 2000. CD1c molecules broadly survey the endocytic system. Proc. Natl. Acad. Sci. U.S.A. 97:8445‐8450.
   Tada, T., Ohkubo, I., Niwa, M., Sasaki, M., Tateyama, H., and Eimoto, T. 1991. Immunohistochemical localization of Zn‐alpha 2‐glycoprotein in normal human tissues. J. Histochem. Cytochem. 39:1221‐1226.
   Tazi, A., Bouchonnet, F., Grandsaigne, M., Boumsell, L., Hance, A.J., and Soler, P. 1993. Evidence that granulocyte macrophage‐colony‐stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J. Clin. Invest. 91:566‐576.
   Teitell, M., Cheroutre, H., Panwala, C., Holcombe, H., Eghtesady, P., and Kronenberg, M. 1994. Structure and function of H‐2 T (Tla) region class I MHC molecules. Crit. Rev. Immunol. 14:1‐27.
   Tsujimura, K., Obata, Y., Iwase, S., Matsudaira, Y., Ozeki, S., and Takahashi, T. 2000. The epitope detected by cytotoxic T lymphocytes against thymus leukemia (TL) antigen is TAP independent. Int. Immunol. 12:1217‐1225.
   Ulker, N., Lewis, K.D., Hood, L.E., and Stroynowski, I. 1990. Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa‐2 antigen. EMBO J. 9:3839‐3847.
   Ungchusri, T., Chiang, E.Y., Brown, G., Chen, M., Tabaczewski, P., Timares, L., and Stroynowski, I. 2001. Widespread expression of the nonclassical class I Qa‐2 antigens in hemopoietic and nonhemopoietic cells. Immunogenetics 53:455‐467.
   Wainwright, S.D., Biro, P.A., and Holmes, C.H. 2000. HLA‐F Is a predominantly empty, intracellular, TAP‐associated MHC class Ib protein with a restricted expression pattern. J. Immunol. 164:319‐328.
   Wang, Q. and Flaherty, L. 1996. Developmental expression of the mouse MHC Q genes. Eur. J. Immunogenet. 23:121‐127.
   Wang, C.R. and Lindahl, K.F. 1993. Organization and structure of the H‐2M4‐M8 class I genes in the mouse major histocompatibility complex. Immunogenetics 38:258‐271.
   Wang, C.R., Loveland, B.E., and Lindahl, K.F. 1991. H‐2M3 encodes the MHC class I molecule presenting the maternally transmitted antigen of the mouse. Cell 66:335‐345.
   Wang, Q., Geliebter, J., Tonkonogy, S., and Flaherty, L. 1993. Expression of the Q2 gene of the MHC in thymus and intestinal epithelial cells. Immunogenetics 38:370‐372.
   Watts, S., Davis, A.C., Gaut, B., Wheeler, C., Hill, L., and Goodenow, R.S. 1989. Organization and structure of the Qa genes of the major histocompatibility complex of the C3H mouse: Implications for Qa function and class I evolution. EMBO J. 8:1749‐1759.
   Widmark, E., Ronne, H., Hammerling, U., Servenius, B., Larhammar, D., Gustafsson, K., Bohme, J., Peterson, P.A., and Rask, L. 1988. Family relationships of murine major histocompatibility complex class I genes. Sequence of the T2Aa pseudogene, a member of gene family 3. J. Biol. Chem. 263:7055‐7059.
   Wilson, I.A. and Bjorkman, P.J. 1998. Unusual MHC‐like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. Curr. Opin. Immunol. 10:67‐73.
   Wu, M., Van Kaer, L., Itohara, S., and Tonegawa, S. 1991. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. J. Exp. Med. 174:213‐218.
   Yamaguchi, H., Hirai, M., Kurosawa, Y., and Hashimoto, K. 1997. A highly conserved major histocompatibility complex class I‐related gene in mammals. Biochem. Biophys. Res. Commun. 238:697‐702.
   Zappacosta, F., Tabaczewski, P., Parker, K.C., Coligan, J.E., and Stroynowski, I. 2000. The murine liver‐specific nonclassical MHC class I molecule Q10 binds a classical peptide repertoire. J. Immunol. 164:1906‐1915.
   Zhu, X., Meng, G., Dickinson, B.L., Li, X., Mizoguchi, E., Miao, L., Wang, Y., Robert, C., Wu, B., Smith, P.D., Lencer, W.I., and Blumberg, R.S. 2001. MHC class I‐related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J. Immunol. 166:3266‐3276.
   Zwirner, N.W., Fernandez‐Vina, M.A., and Stastny, P. 1998. MICA, a new polymorphic HLA‐related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes. Immunogenetics 47:139‐148.
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