Overview of Protein Folds in the Immune System

Peter D. Sun1, Jeffrey C. Boyington1

1 National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland
Publication Name:  Current Protocols in Immunology
Unit Number:  Appendix 1N
DOI:  10.1002/0471142735.ima01ns44
Online Posting Date:  November, 2001
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The rapid advancement of X‐ray crystallography and nuclear magnetic resonance techniques in recent years has resulted in the solution of macromolecular structures at an unprecedented rate. This review aims at providing a comprehensive description of structures and folds related to the function of the immune system. Focus is placed on immunologically relevant proteins such as immunoreceptors and major histocompatibility complexes. Information is also provided regarding protein structure data banks.

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Table of Contents

  • Access to the Protein Structural Data Bank
  • Immunoglobulins and the Immunoglobulin‐Like Fold
  • The MHC Peptide‐Binding Fold
  • Proteasome
  • Proteins Involved in Signal Transductions: Cytokines
  • Proteins Involved in Signal Transduction: Cell Surface Receptors
  • Signal Transduction: Modular Domains
  • Signal Transduction: Protein Kinases and Phosphatases
  • Proteins in the Complement System
  • DNA‐Binding Proteins
  • Antimicrobial Peptides: Defensins
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

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