Nomenclature of the Human T Cell Receptor Genes

Marie‐Paule Lefranc1

1 Université Montpellier II, CNRS, Montpellier
Publication Name:  Current Protocols in Immunology
Unit Number:  Appendix 1O
DOI:  10.1002/0471142735.ima01os40
Online Posting Date:  May, 2001
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Abstract

The human T cell receptors (TcR) α‐β and γ‐δ are the products of four sets of genes on two chromosomes: T cell receptors α (TRA) and δ (TRD) on chromosome 14 at 14q11.2, T cell receptor β (TRB) on chromosome 7 at 7q35, and T cell receptor γ (TRG) on chromosome 7 at 7p15‐p14. This appendix presents tabulated lists of the human TcR α, β, γ, and δ genes named in accordance with the International ImMunoGeneTics database and approved by the Human Genome Organization Nomenclature Committee in 1999. Two additional tables list corresponding nomenclatures for these genes.

     
 
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Table of Contents

  • Human T Cell Receptor Loci
  • Table Guide
  • Acknowledgements
  • Figures
  • Tables
     
 
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Materials

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Literature Cited

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Key References
   Giudicelli, V. and Lefranc, M.‐P. 1999. Ontology for immunogenetics: IMGT‐ONTOLOGY. Bioinformatics 15:1047‐1054.
   The immunoglobulin gene nomenclature is based on the CLASSIFICATION concept of the IMGT‐ONTOLOGY.
   Lefranc and Rabbitts, 1990a. See above.
   This paper describes the rules for a standardized nomenclature of the T cell receptor genes.
   Ruiz, M., Giudicelli, V., Ginestoux, C., Stoehr, P., Robinson, J., Bodmer, J., Marsh, S.G.E., Bontrop, R., Lemaitre, M., Lefranc, G., Chaume, D., and Lefranc, M.‐P. 2000. IMGT, the international ImMunoGeneTics database. Nucl. Acids Res. 28:219‐221.
  The immunoglobulin gene nomenclature is part of the data standardization in the international ImMunoGeneTics database.
Internet Resources
   http://www.gdb.org
  The Genome Database.
   http://www.gene.ucl.ac.uk/nomenclature
  HUGO Gene Nomenclature Committee web site.
   http://imgt.cines.fr:8104
  IMGT, the international ImMunoGeneTics database. IMGT/LIGM‐DB contains the germline and rearranged sequences of the immunoglobulin and T cell receptor genes of human and other vertebrates.
   http://imgt.cines.fr:8104/textes/IMGTrepertoire.html
  IMGT Repertoire provides locus representations, germline gene tables, potential germline repertoires, correspondence between gene nomenclatures, protein displays, alignments of alleles, and tables of alleles for all the human TRA, TRB, TRG and TRD genes. 2D graphical representations designated as Colliers de Perles are provided for the variable genes.
   http://imgt.cines.fr:8104/textes/IMGTScientificChart.html
  IMGT Scientific chart describes the rules for a standardized immunoglobulin and T cell receptor gene and allele nomenclature.
   http://www.ncbi.nlm.nih.gov/LocusLink
  NCBI LocusLink.
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