Nomenclature of the Human Immunoglobulin Genes

Marie‐Paule Lefranc1

1 Université Montpellier II, CNRS, Montpellier
Publication Name:  Current Protocols in Immunology
Unit Number:  Appendix 1P
DOI:  10.1002/0471142735.ima01ps40
Online Posting Date:  May, 2001
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Abstract

The human immunoglobulins (Ig) are the products of three unlinked sets of genes: the immunoglobulin heavy (IGH), the immunoglobulin κ (IGK), and the immunoglobulin λ (IGL) genes, localized on chromosome 14 (14q32.33), 2 (2p12), and 22 (22q11.2), respectively. This appendix presents tabulated lists of the human immunoglobulin heavy, κ, and λ genes named in accordance with the International ImMunoGeneTics database (IMGT) and approved by the Human Genome Organization (HUGO) Nomenclature Committee in 1999. Three additional tables list corresponding nomenclatures for these genes.

     
 
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Table of Contents

  • Human Ig Loci
  • Table Guide
  • Acknowledgements
  • Figures
  • Tables
     
 
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Materials

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Figures

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Literature Cited

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Key References
   Giudicelli, V. and Lefranc, M.‐P. 1999. Ontology for immunogenetics: IMGT‐ONTOLOGY. Bioinformatics 15:1047‐1054.
  The immunoglobulin gene nomenclature is based on the CLASSIFICATION concept of the IMGT‐ONTOLOGY.
   Ruiz, M., Giudicelli, V., Ginestoux, C., Stoehr, P., Robinson, J., Bodmer, J., Marsh, S.G.E., Bontrop, R., Lemaitre, M., Lefranc, G., Chaume, D., and Lefranc, M.‐P. 2000. IMGT, the international ImMunoGeneTics database. Nucl. Acids Res. 28:219‐221.
  The immunoglobulin gene nomenclature is part of the data standardization in the international ImMunoGeneTics database.
Internet Resources
   http://www.gene.ucl.ac.uk/nomenclature
  Human Genome Organization (HUGO) Nomenclature Committee.
   http://imgt.cines.fr:8104
  IMGT, the international ImMunoGeneTics database. IMGT/LIGM‐DB contains the germline and rearranged sequences of the immunoglobulin and T cell receptor genes of human and other vertebrates.
   http://imgt.cines.fr:8104/textes/IMGTrepertoire.html
   “IMGT Repertoire”: provides locus representations, germline gene tables, potential germline repertoires, correspondence between gene nomenclatures, protein displays, alignments of alleles, and tables of alleles for all the human IGH, IGK and IGL genes. 2D graphical representations designated as “Colliers de Perles” are provided for the variable genes.
   http://imgt.cines.fr:8104/textes/IMGTrepertoire/1/locus/human/IGH/Hu_IGHcellines.html
  Available cell lines with IGHC multigene deletions.
   http://imgt.cines.fr:8104/textes/IMGTScientificChart.html
   “IMGT Scientific chart”: describes the rules for a standardized immunoglobulin and T cell receptor gene and allele nomenclature.
   http://www.gdb.org
  The Genome Database.
   http://www.ncbi.nlm.nih.gov/LocusLink
  NCBI LocusLink.
   imgt@ligm.igh.cnrs.fr
  E‐mail address of the IMGT curators.
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