Paired Receptor Systems of the Innate Immune System

Eriko Yamada1, Daniel W. McVicar1

1 Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute–Frederick, Frederick, Maryland
Publication Name:  Current Protocols in Immunology
Unit Number:  Appendix 1X
DOI:  10.1002/0471142735.ima01xs81
Online Posting Date:  May, 2008
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Abstract

This appendix describes paired receptors involved in the innate immune system. “Paired Receptors” are defined as families of related membrane proteins that show the following characteristics: (1) they are encoded by different genes, but located as a gene cluster on a given chromosome; (2) they have significant homology within their extracellular domains; (3) they are expressed on overlapping immune populations; and (4) they are confirmed to have both activating and inhibitory members. For simplicity in nomenclature, the authors used the official gene nomenclature provided by NCBI and listed all other names in the alias field. Paired receptor information related to both mouse and human systems is included, as some families exist in both species whereas others are important in the study of either human or murine models of disease. Curr. Protoc. Immunol. 81:A.1X.1‐A.1X.25. © 2008 by John Wiley & Sons, Inc.

Keywords: immune regulation; adaptive immunity; cell signaling

     
 
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Table of Contents

  • Introduction
  • Tables
     
 
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Materials

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