Minimizing Variation Due to Genotype and Environment

Carmen A. Argmann1, Johan Auwerx2

1 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 2 Institut de Génétique et de Biologie Moléculaire et Cellulaire and Institut Clinique de la Souris, Illkirch
Publication Name:  Current Protocols in Molecular Biology
Unit Number:  Unit 29A.2
DOI:  10.1002/0471142727.mb29a02s73
Online Posting Date:  February, 2006
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Abstract

Mouse models are increasingly popular tools to study and characterize the molecular and physiological bases for human diseases. Due to the readily available genetic tools to construct mouse models of complex diseases, the flow of efficient and vigilant mouse phenotyping has now become the bottleneck in mouse functional genomics. This unit addresses the importance of minimizing and defining confounding genetic and environmental sources of variability.

Keywords: genotype; phenotype; environment; strain variation; genetic background

     
 
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Table of Contents

  • Genetic Background
  • Environment
  • Conclusion
  • Literature Cited
  • Tables
     
 
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Materials

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Figures

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Literature Cited

Literature Cited
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