Therapeutic Approaches for Clostridium difficile Infections

Jane W. Marsh1, Scott R. Curry1

1 Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, Pennsylvania
Publication Name:  Current Protocols in Microbiology
Unit Number:  Unit 9A.3
DOI:  10.1002/9780471729259.mc09a03s30
Online Posting Date:  October, 2013
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Metronidazole and vancomycin remain the front‐line therapies for most Clostridium difficile infections (CDI). However, recurrent CDI occurs in ∼25% of patients, causing significant morbidity and mortality and healthcare costs. For this population, traditional antibiotic therapies fail and new treatment options are greatly needed. The US Food and Drug Administration recently approved fidaxomicin for CDI treatment. This narrow‐spectrum antibiotic preserves the normal gut microbiota and shows promise as a treatment for severe and recurrent CDI. Monoclonal antibodies and vaccines directed against toxin are currently in clinical trials and represent alternative, non‐antibiotic therapies. Less traditional therapeutic interventions include bacteriotherapy with non‐toxigenic C. difficile and fecal transplant. This commentary will provide an overview of current and forthcoming CDI therapies. Curr. Protoc. Microbiol. 30:9A.3.1‐9A.3.9. © 2013 by John Wiley & Sons, Inc.

Keywords: colitis; antibiotics; diarrhea; vaccine

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Table of Contents

  • Introduction
  • Epidemiology
  • Disruption of Colonization Resistance
  • CDI Risk Factors
  • Host Immunity
  • Antimicrobial Therapies
  • Antimicrobial Treatment Guidelines
  • Alternative Therapeutic Approaches
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

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