Clinical Applications of fMRI

Keith R. Thulborn1, Denise Davis1

1 University of Illinois at Chicago, Chicago, Illinois
Publication Name:  Current Protocols in Magnetic Resonance Imaging
Unit Number:  Unit A6.1
DOI:  10.1002/0471142719.mia0601s00
Online Posting Date:  May, 2001
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Abstract

The clinical scenario in which fMRI is requested by a referring physician is usually after detection of a lesion in the brain of a patient for whom surgical intervention is being contemplated. This unit discusses the suitable parameters of a functional MRI system and also presents the for imaging language function.

     
 
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Table of Contents

  • Basic Protocol 1: Imaging Language Function
  • Commentary
  • Figures
  • Tables
     
 
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Materials

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Figures

  •   FigureFigure a0.60.1 Representative activation map at 3.0 T for language paradigm, showing extensive network activation with areas of fronta eye fields (FEF, precentral sulcus), supplementary eye fields (SEF, medial frontal cortex), prefrontal cortex (PFC), intraparietal sulcus (IPS), Broca's area (BA, left inferior frontal cortex), Wernicke's area (WA, left superior temporal gyrus), and visual cortex (calcarine sulcus). This pattern is observed in adults irrespective of gender or handedness. The right inferior frontal cortex also shows activation in the contralateral location to Broca's area as can sometimes be observed with Wernicke's area. The color scale indicates the t‐test statistic for activation. The higher t‐statistic (yellow) has greater statistical significance. See color plate.

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Literature Cited

Literature Cited
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Key Reference
   Moonen, C. and Bandettini, P. (eds.) 1999. Medical Radiology: Diagnostic Imaging and Radiation Oncology, Functional MRI. Springer‐Verlag, Berlin.
  Comprehensive book on all issues related to fMRI
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