Paradigms for Clinical fMRI

Keith R. Thulborn1, Denise Davis1

1 University of Illinois at Chicago, Chicago, Illinois
Publication Name:  Current Protocols in Magnetic Resonance Imaging
Unit Number:  Unit A6.3
DOI:  10.1002/0471142719.mia0603s00
Online Posting Date:  May, 2001
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Abstract

This unit presents description of four basic clinical paradigms for clinical fMRI of language cmprehension, eye movement (visually guidede saccades), motor cortex (finger‐thumb apposition), and visual cortex. Given the neurosurgical concern with preservation of eloquent cortex, brain functions of particular interest are primary sensory (e.g., visual, auditory) and motor functions, and high level processing of language comprehension and expression. Compromise of these functions is usually readily apparent clinically and the quality of life of the patient is severely diminished. Functional MRI offers a means to locate these functions, thereby allowing the surgeon to plan on preserving these functions, or prepare the patient appropriately.

     
 
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Table of Contents

  • Paradigms
  • Commentary
  • Literature Cited
  • Figures
     
 
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Materials

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Figures

Videos

Literature Cited

Literature Cited
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   Thulborn, K.R., Carpenter, P.A., and Just, M.A. 1999a. Plasticity of language‐related brain function during recovery from stroke. Stroke 30:749‐754.
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   Thulborn, K.R., Martin, C., and Voyvodic, J. 2000. fMRI using a visually guided saccade paradigm in Alzheimer's disease. Am. J. Neuroradiol. 21:524‐531.
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