Mouse Strains and Genetic Nomenclature

Jean‐Louis Guénet1, Fernando J. Benavides2

1 Département de Biologie du Développement, Institut Pasteur, Paris, France, 2 The University of Texas M.D. Anderson Cancer Center, Science Park‐Research Division, Smithville, Texas
Publication Name:  Current Protocols in Mouse Biology
Unit Number:   
DOI:  10.1002/9780470942390.mo100181
Online Posting Date:  March, 2011
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In this article we describe the main characteristics and peculiarities of the different strains and stocks of laboratory animals from the genetic point of view. We explain how they are produced and maintained as well as their advantages and disadvantages in the context of animal experiments. We also provide some guidance to make the best possible choice when establishing an experimental protocol. Curr. Protoc. Mouse Biol. 1:213‐238. © 2011 by John Wiley & Sons, Inc.

Keywords: inbred strains; congenic strains; recombinant inbred strains; recombinant congenic strains; outbred stocks

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Table of Contents

  • The Different Categories of Laboratory Strains and Stocks
  • Inbred Strains and Their Derivatives
  • Outbred and Randombred Stocks
  • Nomenclature Rules for Mouse and Rat Strains
  • Conclusions
  • Warning!
  • Literature Cited
  • Figures
  • Tables
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  In 2001, the International Committee on Standardized Nomenclature for Mice (Chairperson: Dr. Janan T. Eppig) and the Rat Genome and Nomenclature Committee (Chairperson: Dr. Göran Levan) agreed to establish a joint set of rules for strain nomenclature, applicable to strains of both species. These guidelines are updated annually by the international nomenclature committees. The official Web site for these guidelines may be found at the above URL.
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  An annotated list of mouse and rat inbred strain.
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