Mouse Strains and Genetic Nomenclature

Jean‐Louis Guénet1, Fernando J. Benavides2

1 Département de Biologie du Développement, Institut Pasteur, Paris, France, 2 The University of Texas M.D. Anderson Cancer Center, Science Park‐Research Division, Smithville, Texas
Publication Name:  Current Protocols in Mouse Biology
Unit Number:   
DOI:  10.1002/9780470942390.mo100181
Online Posting Date:  March, 2011
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Abstract

In this article we describe the main characteristics and peculiarities of the different strains and stocks of laboratory animals from the genetic point of view. We explain how they are produced and maintained as well as their advantages and disadvantages in the context of animal experiments. We also provide some guidance to make the best possible choice when establishing an experimental protocol. Curr. Protoc. Mouse Biol. 1:213‐238. © 2011 by John Wiley & Sons, Inc.

Keywords: inbred strains; congenic strains; recombinant inbred strains; recombinant congenic strains; outbred stocks

     
 
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Table of Contents

  • The Different Categories of Laboratory Strains and Stocks
  • Inbred Strains and Their Derivatives
  • Outbred and Randombred Stocks
  • Nomenclature Rules for Mouse and Rat Strains
  • Conclusions
  • Warning!
  • Literature Cited
  • Figures
  • Tables
     
 
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Materials

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Literature Cited

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INTERNET RESOURCES
  http://www.informatics.jax.org/mgihome/nomen/strains.shtml
  In 2001, the International Committee on Standardized Nomenclature for Mice (Chairperson: Dr. Janan T. Eppig) and the Rat Genome and Nomenclature Committee (Chairperson: Dr. Göran Levan) agreed to establish a joint set of rules for strain nomenclature, applicable to strains of both species. These guidelines are updated annually by the international nomenclature committees. The official Web site for these guidelines may be found at the above URL.
  http://phenome.jax.org/
  Official Web site of The Mouse Phenome Project, an international collaboration representing five countries in both the academic and corporate sectors. Its aim is to establish a collection of baseline phenotypic data on commonly used and genetically diverse inbred mouse strains through a coordinated effort.
  http://www.informatics.jax.org/external/festing/search_form.cgi
  An annotated list of mouse and rat inbred strain.
  http://www.isogenic.info/html/animal_models_in_research.html
  Dr. M. F. W. Festing's Web site about the best use of animal models.
  http://www.informatics.jax.org/morsebook/
  Electronic version of the book by Herbert C. Morse III, Origins of Inbred Mice, Academic Press. 1978.
  http://www.informatics.jax.org/silverbook/
  Electronic version of the book by Lee M. Silver. 1995. Mouse Genetics: Concepts and Applications, Oxford University Press.
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