Overview of Formation of G‐Quadruplex Structures

Yuta Sannohe1, Hiroshi Sugiyama2

1 Kyoto University, Kyoto, Japan, 2 Japan Science and Technology Corporation (CREST), Tokyo, Japan
Publication Name:  Current Protocols in Nucleic Acid Chemistry
Unit Number:  Unit 17.2
DOI:  10.1002/0471142700.nc1702s40
Online Posting Date:  March, 2010
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Abstract

There are many structures that can be adopted by nucleic acids other than the Watson‐Crick duplex. In particular, a noncanonical four‐stranded topology, called a G‐quadruplex, is of great interest because of its roles in key biological processes such as the maintenance of telomeres and regulation of gene transcription. This review describes the condition for forming the G‐quadruplex structure, G‐quadruplex‐forming sequences, and methods for studying the structures. Curr. Protoc. Nucleic Acid Chem. 40:17.2.1‐17.2.17. © 2010 by John Wiley & Sons, Inc.

Keywords: DNA structure; quadruplex‐forming sequences; methods; conditions

     
 
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Table of Contents

  • Introduction
  • Conditions for Forming the G‐Quadruplex Structure
  • Methods for Studying G‐Quadruplex Structures
  • G‐Quadruplex‐Forming Sequences
  • Conclusion and Future Directions
  • Acknowledgements
  • Literature Cited
  • Figures
     
 
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Materials

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Literature Cited

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