Characteristics of Nucleic Acids

Donald E. Bergstrom1

1 Purdue University, West Lafayette
Publication Name:  Current Protocols in Nucleic Acid Chemistry
Unit Number:  Appendix 1B
DOI:  10.1002/0471142700.nca01bs00
Online Posting Date:  May, 2001
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Abstract

This appendix is a compilation of information from Current Protocols in Molecular Biology (John Wiley & Sons, Inc.) and provides information about the major nucleoside/nucleotide constituents and structures for A‐, B‐, and Z‐DNA. Tables and figures provide (1) experimentally useful properties of the nucleoside/nucleotide building blocks; (2) chemical structures of the nucleosides; (3) aspects of nucleotide stereochemistry that are important to an understanding of base pairing and secondary structure; (4) alternative (non‐Watson‐Crick) base pairings; and (5) the three best characterized helix structures for DNA: A‐, B‐, and Z‐DNA.

     
 
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Table of Contents

  • Literature Cited
  • Figures
  • Tables
     
 
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Materials

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Figures

Videos

Literature Cited

Literature Cited
   Burkard, M.E., Turner, D.H., Tinoco, I. Jr. 1999. Structure of base pairs involving at least two hydrogen bonds. In RNA World, 2nd ed. (R.F. Gesteland, T.R. Cech, and J.F. Atkins eds.) pp. 675‐680, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Dawson, M.C., Elliott, D.C., Elliott, W.H., and Jones, K.M. (eds.). 1987. Data for Biochemical Research, 3rd ed. Clarendon Press, Oxford.
   Dickerson, R.E. 1989. Definitions and nomenclature of nucleic acid structure components. Nucl. Acids Res. 17:1797‐1803.
   Dickerson, R.E. 1992. DNA structure from A to Z. Methods Enzymol. 211:67‐111.
   Fasman, G. (ed.). 1975. Handbook of Biochemistry and Molecular Biology,Vol. 1:Nucleic Acids, 3rd ed. CRC Press, Boca Raton, Fla.
   Hartman, B. and Lavery, R. 1996. DNA structural forms. Q. Rev. Biophys. 29:309‐368.
   Heinemann, U., Ailings, C., and Hahn, M. 1994. Crystallographic studies of DNA helix structure. Biophys. Chem. 50:157‐176.
   Neidle, S. 1999. Oxford Handbook of Nucleic Acid Structure. Oxford University Press, Oxford.
   Radhakrishnan, I. and Patel, D.J. 1994. DNA triplexes: solution structures, hydration sites, energetics, interactions, and function. Biochemistry. 33:11405‐11416.
   Saenger, W. 1984. Principles of Nucleic Acid Structure. Springer‐Verlag, New York.
   Sen, D. and Gilbert, W. 1988. Formation of parallel four‐stranded complexes by guanine‐rich motifs in DNA and its implications for meiosis. Nature 334:364‐366.
   T'so, P.O.P. 1974. Bases, nucleosides, and nucleotides. In Basic Principles in Nucleic Acid Chemistry,Vol. 1 (P.O.P. T'soed.) pp. 453‐584. Academic Press, San Diego.
   Wang, A.H., Quigley, G.J., Kolpak, F.J., Crawford, J.L., van Boom, J.H., van der Marel, G., and Rich, A. 1979. Molecular structure of a left‐handed double helical DNA fragment at atomic resolution. Nature 282:680‐686.
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