Overview of Nucleic Acid Arrays

Joseph DeRisi1

1 University of California, San Francisco, San Francisco, California
Publication Name:  Current Protocols in Neuroscience
Unit Number:  Unit 4.25
DOI:  10.1002/0471142301.ns0425s16
Online Posting Date:  November, 2001
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Abstract

Nucleic acid array technology refers to the use and fabrication of arrays containing thousands of nucleic acid samples bound to solid substrates such as glass microscope slides or silicon wafers. Because the physical area occupied by each sample is usually 50 to 200 micrometers in diameter, it is possible to assay nucleic acid samples representing entire genomes, ranging in size from 3,000 to 32,000 genes, on a single slide. Microarrays are useful for analyzing gene expression patterns, genotyping and genetic mapping, comparative genomic hybridization, polysome analysis, and DNA‚Äźprotein interactions. This overview describes the technology and applications, and provides valuable web site listings for obtaining additional information.

     
 
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Table of Contents

  • What are Microarrays Good for?
  • What Else are Nucleic Acid Microarrays Good for?
  • What About Data Analysis?
  • Where Can I Get More Information?
  • Literature Cited
  • Figures
     
 
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Materials

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Figures

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Literature Cited

Literature Cited
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