Direct, Continuous Behavioral Analysis of Drug Action on Feeding
Analysis of rodent feeding behavior during the study of anorectic drugs reveals that contextual variables such as type of food, drug, environment, and physiological state influence food intake. Temporal changes in behavior can signal the onset of a feeding modulation process, as is the case with anorectic drugs acting on distinct neurochemical mechanisms that change temporal behavioral profiles. Comparing the effects of anorectic agents in controlled animal assays can identify potential therapeutic drugs that may influence human eating behavior. This unit specifies the materials and procedures required for continuously monitoring the Behavioral Satiety Sequence, as well as a device for continuous, automatic measurement of the mass of food consumption by the animal during behavioral monitoring called the RUEMA (Rat Universal Eating Monitor Apparatus).
Figure 8.6C.1 Temporal characteristics evident in the Behavioral Satiety Sequence.
Figure 8.6C.3 Rat Universal Eating Monitor Apparatus (RUEMA). (A) RUEMA set up on lab bench, showing balance, food cup, and glass observation tank. (B) Cross-section shows the mounted food cup (1), securable collar (2), and digital balance (3).
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Basic student text covering the same areas.
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Advanced text covering the same areas.