Animal Health Assurance

John Donovan1, Patricia Brown2

1 BioResources Consulting, Wayne, Pennsylvania, 2 Office of Animal Care and Use, National Institutes of Health, Bethesda, Maryland
Publication Name:  Current Protocols in Neuroscience
Unit Number:  Appendix 4C
DOI:  10.1002/0471142301.nsa04cs17
Online Posting Date:  February, 2002
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Abstract

A program to assure the health of laboratory animals and to provide a stable environment for their maintenance is necessary to reduce unwanted variables or complicating factors in experimentation. To assure animal health throughout a research study, the animals involved should be procured in good health, monitored for continued health status, and protected from pathogenic organisms through testing of any biological materials. This unit addresses all three of these health management practices. Essential in support of these practices is a diagnostic laboratory capable of testing for rodent and rabbit pathogens.

     
 
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Table of Contents

  • Quarantine and Stabilization
  • Health Monitoring
  • Tables
     
 
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Materials

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Figures

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Literature Cited

Literature Cited
   Landi, M.S., Kreider, J.M., Lang, C.M., and Bullock, L.P. 1982. Effects of shipping on the immune function of mice. Am. J. Vet. Res. 43:1654‐1657.
Key References
  Baker, H.J., Lindsey, J.R., and Manning, P.J. (eds.) The Laboratory Rat, Vol. I: Biology and Diseases (1979); Vol. II: Research Applications (1980). ACLAM Series. Academic Press, San Diego.
   NOTE: The American College of Laboratory Animal Medicine (ACLAM) series of texts listed below provides excellent information on the complications to research of intercurrent infections.
  Foster, H.L., Small, J.D., and Fox, J.G. (eds.) 1981‐1983. The Mouse in Biomedical Research, Vols. I to IV. ACLAM Series. Academic Press, San Diego.
   LaRegina, M.C. and Lonigro, J. 1988. Serologic screening for murine pathogens: Basic concepts and guidelines. Lab. Anim. 17:40‐47.
  Manning, P.J., Ringler, D.H., and Newcomer, C.E. (eds.) 1994. The Biology of the Laboratory Rabbit, 2nd ed. ACLAM Series. Academic Press, San Diego.
   Percy, D.H. and Barthold, S.W. 2001. Pathology of Laboratory Rodents and Rabbits, 2nd ed. Iowa State University Press, Ames, Iowa.
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