Overview of Signal Transduction

Timothy A. Esbenshade1, Emir Duzic2

1 Abbott Laboratories, Abbott Park, Illinois, 2 Cephalon Inc., West Chester, Pennsylvania
Publication Name:  Current Protocols in Pharmacology
Unit Number:  Unit 2.1
DOI:  10.1002/0471141755.ph0201s31
Online Posting Date:  January, 2006
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Receptor‐ and ion channel‐coupled signal transduction mechanisms are downstream communication processes used by regulatory molecules to modulate the essential cell processes of growth, differentiation and survival. Knowledge of signal transduction processes has dramatically increased in the past decade, and the basic principles of intracellular signaling are now quite well established. Cell signaling in higher organisms is a major, highly complex, phenomena that occupies a central position in current biomedical research. The complex machinery of intracellular signaling also has the potential to provide a wealth of novel drug discovery targets, from protein kinases, adaptor proteins, lipases, and cytoskeletal proteins, to nuclear effectors. This overview describes common features of cellular signaling pathways, including their interactions and responses to environmental stimuli. In particular, the overview focuses on the regulation of signaling pathways by protein functional‐domain interactions as well as the intracellular proteins that mediate signal transduction.

Keywords: Protein functional domains; GPCR; 7TM; Heterotrimeric G protein; Phospholipase; Nucleotide Cyclase; Tyrosine Kinase; Serine/Threonine Kinase; Phosphatase; MAPK; Ion Channel

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Table of Contents

  • Protein Functional Modules
  • Intracellular Signaling Proteins
  • Literature Cited
  • Figures
  • Tables
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Key References
   Exton, 2002. See above.
  A review of the intracellular signaling mechanisms associated with phospholipase activation in response to GPCR activation
   Pawson et al., 2005. See above.
  A review of the structure and function of protein modules shared by many signaling intermediates, and the mechanisms by which they mediate protein‐protein interactions
   van Biesen et al., 1996. See above.
  A comprehensive review of mitogenic signaling as mediated by G proteins and GPCRs.
   Schlessinger, 2002. See above.
  A review of the cell signaling mediated by receptor tyrosine kinases
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