Overview of the Use of Transgenic Animals in CNS Drug Discovery

Eric J. Nestler1, Berend Olivier1

1 PsychoGenics, Inc., Tarrytown, New York
Publication Name:  Current Protocols in Pharmacology
Unit Number:  Unit 5.20
DOI:  10.1002/0471141755.ph0520s07
Online Posting Date:  May, 2001
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This overview highlights how transgenic mice, and related genetic manipulations, can contribute in important ways to the goal of developing novel treatments for neuropsychiatric disorders. A brief background of the field of drug discovery is covered and then new animal models of CNS disorders are discussed along with the topics of target validation, identification of novel targets, and functional genomics.

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Table of Contents

  • Drug Discovery in the Molecular Era
  • New Animal Models of CNS Disorders
  • Target Validation
  • Identification of Novel Targets
  • Conclusions
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

Literature Cited
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