Modeling Human Liver Cancer Heterogeneity: Virally Induced Transgenic Models and Mouse Genetic Models of Chronic Liver Inflammation

Marc Ringelhan1, Florian Reisinger2, Detian Yuan2, Achim Weber3, Mathias Heikenwalder2

1 German Center for Infection Research (DZIF), München, 2 Institute of Virology, München, 3 Institute of Surgical Pathology, Zürich
Publication Name:  Current Protocols in Pharmacology
Unit Number:  Unit 14.31
DOI:  10.1002/0471141755.ph1431s67
Online Posting Date:  December, 2014
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In addition to being the most common primary liver cancer, hepatocellular carcinoma (HCC) is the second most common cause of cancer‐related death in humans. Treatment options are limited for this chemoresistant cancer, with liver transplantation and surgical intervention in early stages being the most successful treatments. Drug development over the past 15 years has focused on generating mouse models that mimic the human pathology for HCC. This has enabled the laboratory testing of potentially new human therapeutics. Described in this unit are the classification of HCC and an overview of hepatitis virus‐related transgenic and genetically engineered mouse models (GEMMs) that are employed for elucidating the mechanism(s) responsible for the development of HCC, with particular emphasis on genetic, dietary, and environmental factors. © 2014 by John Wiley & Sons, Inc.

Keywords: mouse model; chronic liver inflammation; HCC; liver cancer; modeling human disease

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Table of Contents

  • Introduction
  • Classifications for Human HCC
  • Mouse Genetic Models Mimicking Chronic Inflammation and Chronic Liver Damage
  • Apoptosis and Proliferation‐Induced HCC
  • Models of NAFLD/NASH‐Driven HCC
  • Models for Virus‐Induced Liver Cancer (Table )
  • HBV‐Related Transgenic Models of HCC
  • HCV‐Related Transgenic Models of HCC
  • Xenograft Mouse Models
  • Challenges in HCC Mouse Models and Future Opportunities
  • Acknowledgements
  • Literature Cited
  • Figures
  • Tables
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