Overview of Genetically Engineered Mouse Models of Papillary and Anaplastic Thyroid Cancers: Enabling Translational Biology for Patient Care Improvement

Roch‐Philippe Charles1

1 Institut für Biochemie und Molekulare Medizin, University of Bern, Bern
Publication Name:  Current Protocols in Pharmacology
Unit Number:  Unit 14.33
DOI:  10.1002/0471141755.ph1433s69
Online Posting Date:  June, 2015
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The prognosis from thyroid cancer subtypes in humans covers a spectrum from “cured at almost 90%” to “100% lethal.” Invasive and poorly differentiated forms of thyroid cancer are among the most aggressive human cancers, and there are few effective therapeutic options. Genetically engineered mice, based on mutations observed in patients, can accurately recapitulate the human disease and its progression, providing invaluable tools for the preclinical evaluation of novel therapeutic approaches. This overview details models developed to date as well as their uses for identifying novel anticancer agents. © 2015 by John Wiley & Sons, Inc.

Keywords: genetically engineered mice; papillary and anaplastic thyroid cancer; pre‐clinical platform; cancer model; BRAF mutations

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Table of Contents

  • Introduction
  • Xenograft Models
  • Models Based on Direct Transgene Expression
  • Models Based on Conditional Mutations
  • Tumor Burden Imaging and the Use of Thyroid Cancer GEM Models for Evaluation of Anti‐Cancer Agents
  • Conclusion
  • Disclosure of Potential Conflicts of Interest
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

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