Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes

Jerry Usary1, David Brian Darr1, Adam D. Pfefferle1, Charles M. Perou1

1 Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
Publication Name:  Current Protocols in Pharmacology
Unit Number:  Unit 14.38
DOI:  10.1002/0471141755.ph1438s72
Online Posting Date:  March, 2016
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Advances in the screening of new therapeutic options have significantly reduced the breast cancer death rate over the last decade. Despite these advances, breast cancer remains the second leading cause of cancer death among women. This is due in part to the complexity of the disease, which is characterized by multiple subtypes that are driven by different genetic mechanisms and that likely arise from different cell types of origin. Because these differences often drive treatment options and outcomes, it is important to select relevant preclinical model systems to study new therapeutic interventions and tumor biology. Described in this unit are the characteristics and applications of validated genetically engineered mouse models (GEMMs) of basal‐like, luminal, and claudin‐low human subtypes of breast cancer. These different subtypes have different clinical outcomes and require different treatment strategies. These GEMMs can be considered faithful surrogates of their human disease counterparts. They represent alternative preclinical tumor models to cell line and patient‐derived xenografts for preclinical drug discovery and tumor biology studies. © 2016 by John Wiley & Sons, Inc.

Keywords: gene expression; breast cancer; mouse models; drug testing; efficacy prediction

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Table of Contents

  • Introduction
  • GEMM Characterization
  • Translational Application of GEMMs
  • Summary
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

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