Overview of Protein Structural and Functional Folds

Peter D. Sun1, Christine E. Foster1, Jeffrey C. Boyington2

1 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, 2 National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina
Publication Name:  Current Protocols in Protein Science
Unit Number:  Unit 17.1
DOI:  10.1002/0471140864.ps1701s35
Online Posting Date:  May, 2004
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This overview provides an illustrated, comprehensive survey of some commonly observed protein‐fold families and structural motifs, chosen for their functional significance. It opens with descriptions and definitions of the various elements of protein structure and associated terminology. Following is an introduction into web‐based structural bioinformatics that includes surveys of interactive web servers for protein fold or domain annotation, protein‐structure databases, protein‐structure‐classification databases, structural alignments of proteins, and molecular graphics programs available for personal computers. The rest of the overview describes selected families of protein folds in terms of their secondary, tertiary, and quaternary structural arrangements, including ribbon‐diagram examples, tables of representative structures with references, and brief explanations pointing out their respective biological and functional significance.

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Table of Contents

  • Introduction to Protein Structure
  • Web‐Based Structural Bioinformatics
  • Proteins Involved in the Function of Immune Systems
  • Proteins Involved in Signal Transduction Pathways
  • DNA‐Binding Structural Motifs and Domains
  • RNA‐Binding Structural Motifs and Domains
  • Carbohydrate‐Binding Proteins
  • Calcium‐Binding Proteins
  • Nucleotide‐Binding Domains
  • Enzymes Involved in DNA/RNA Replication and DNA Transcription
  • Proteins Involved in Cytoskeleton and Muscle Movements
  • Enzymes
  • Electron Transfer Proteins
  • Globin‐Like Proteins
  • Toxins
  • Lipid‐Binding Proteins
  • Large Multisubunit Proteins
  • Integral Membrane Proteins
  • Acknowledgements
  • Appendix
  • Literature Cited
  • Figures
  • Tables
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