Hideaki Nagase1

1 Imperial College School of Medicine, London
Publication Name:  Current Protocols in Protein Science
Unit Number:  Unit 21.4
DOI:  10.1002/0471140864.ps2104s24
Online Posting Date:  August, 2001
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Metalloproteases (metallopeptidases) are composed of a diverse group of endopeptidases and exopeptidases. Because metalloproteases play key roles in many normal biological processes, their aberrant activities have been implicated in diseases such as arthritis, cancer, cardiovascular diseases, nephritis, disorders in the central nervous system, fibrosis, and infection, as well as others. This unit provides an overview of metalloproteases, including their classification, catalytic mechanisms, structures, substrate specificities, and common inhibitors.

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Table of Contents

  • Classification
  • Catalytic Mechanisms
  • Mosaic Structures of Metallopeptidases and Substrate Specificity
  • Metalloprotease Inhibitors
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

Literature Cited
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   Barrett, A.J., Rawlings, N.D., and Woessner, J.F. (eds.) 1998. Handbook of Proteolytic Enzymes. Academic Press, London.
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