An Overview of Serine Proteases

Lizbeth Hedstrom1

1 Brandeis University, Waltham, Massachusetts
Publication Name:  Current Protocols in Protein Science
Unit Number:  Unit 21.10
DOI:  10.1002/0471140864.ps2110s26
Online Posting Date:  February, 2002
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This unit summarizes the families of serine proteases and their mechanism of catalysis. Methods for assays and determining substrate specificity are briefly described. The mode of action of commonly available inhibitors is also included.

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Table of Contents

  • Families of Serine Proteases
  • Serine Protease Precursors
  • The Mechanism of the Serine Protease Reaction
  • Specificity of Serine Proteases
  • Assays of Serine Proteases
  • Inhibitors
  • Expression of Serine Proteases
  • Figures
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Literature Cited

Literature Cited
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Internet Resources∼protease/index.html
  Rose and Di Cera serine protease home page.
  MEROPS data base.‐bin/lists?peptidas.txt
  ExPASy website.
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