Zebrafish: An Animal Model for Toxicological Studies

Chaojie Zhang1, Catherine Willett1, Trisha Fremgen2

1 Phylonix Pharmaceuticals, Cambridge, Massachusetts, 2 Northeastern University, Boston, Massachusetts
Publication Name:  Current Protocols in Toxicology
Unit Number:  Unit 1.7
DOI:  10.1002/0471140856.tx0107s17
Online Posting Date:  November, 2003
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Zebrafish (Danio rerio) has been extensively studied and well described for environmental toxicity studies. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. The versatile zebrafish is now incorporated in many areas of toxicological programs for assessing human risk and for preclinical drug discovery and screening.

Keywords: zebrafish; animal model; toxicity; developmental toxicity; drug testing

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Table of Contents

  • Zebrafish as an Animal Model
  • Zebrafish Developmental and Genetic Studies
  • Toxicological Studies
  • Toxicity Testing of Therapeutics: A Comprehensive Approach Using Zebrafish
  • Organ Toxicity
  • Toxicity‐Related Cell Death
  • Summary
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

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