Minipigs: Applications in Toxicology

Larry D. Brown1, Alain Stricker‐Kongrad1, Guy F. Bouchard1

1 Sinclair Research Center, LLC and Sinclair BioResources, LLC, Auxvasse, Missouri
Publication Name:  Current Protocols in Toxicology
Unit Number:  Unit 1.11
DOI:  10.1002/0471140856.tx0111s56
Online Posting Date:  May, 2013
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Abstract

Minipigs are accepted models for a variety of drug preclinical and nonregulatory toxicology studies. Acute, subchronic and chronic studies are possible using all routes of administration. Minipigs have distinct size advantages over domestic pigs. There exist some minor limitations with minipigs, but for the most part they offer well correlated models to humans for dermal and systemic toxicology assessments. Phototoxicology and reproductive toxicology usage is expanding. Minipig size, anatomy, physiology, metabolism, and genetics generally correlate well to human factors. The minipig makes an appropriate model for toxicology. Curr. Protoc. Toxicol. 56:1.11.1‐1.11.19. © 2013 by John Wiley & Sons, Inc.

Keywords: minipig; toxicology; animal model

     
 
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Table of Contents

  • Introduction
  • Selection of Animal Species
  • Numbers of Minipigs Studied: Europe Versus USA
  • Advantages and Limitations of Minipig Toxicology Models
  • Miniswine Lineage/Breed Selection for Toxicology
  • Correlation of Toxicology Study Findings
  • Dermatotoxicology/Cutaneous Safety Assessment
  • Ocular Safety Evaluation
  • Cardiovascular Toxicology
  • Nephrotoxicology
  • Developmental Immunology and Immunotoxicology
  • Liver Metabolism and Hepatotoxicology
  • Toxicokinetic Studies
  • Device Safety
  • Safety Pharmacology
  • Reproductive and Developmental Toxicology (DART)
  • Phototoxicology
  • Hematopoietic Toxicology
  • Minipig Repeat Intravenous Infusion Studies
  • Serum Enzymes in Toxicology
  • Confounders in Toxicology
  • Human Correlation/Concordance for Toxicology
  • Lineage Selection
  • Summary and the Future
  • Literature Cited
  • Figures
  • Tables
     
 
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Materials

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Literature Cited

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