Current Concepts in Cell Toxicity

Afshin Samali1, Boris Zhivotovsky1, Sten Orrenius1

1 Karolinska Institutet, Stockholm
Publication Name:  Current Protocols in Toxicology
Unit Number:  Unit 2.1
DOI:  10.1002/0471140856.tx0201s00
Online Posting Date:  May, 2001
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This overview provides a basic definition of cellular death and the mechanisms that are associated with cell death: apoptosis and necrosis. It includes a description of structural changes and macromolecular degradation and the roles of signaling, mitochondria, and genetic changes in the two forms of cell death.

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Table of Contents

  • Cell Death
  • Structural Changes During Cell Death
  • Macromolecular Degradation During Cell Death
  • Cellular Signaling During Cell Death
  • Role of Mitochondria During Cell Death
  • Genetic Modulation of Apoptotic Cell Death
  • Conclusions
  • Literature Cited
  • Tables
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Literature Cited

Literature Cited
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