Measurement of Disposition Half‐Life, Clearance, and Residence Times

Michael Mayersohn1

1 The University of Arizona, Tucson, Arizona
Publication Name:  Current Protocols in Toxicology
Unit Number:  Unit 5.3
DOI:  10.1002/0471140856.tx0503s04
Online Posting Date:  May, 2001
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This unit provides an overview of the principles underlying the elimination process. Experimental design issues, methods of data analysis, and complications that may be encountered are discussed. A complete worked example is provided to exemplify the methods of analysis that are available.

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Table of Contents

  • Aims and Objectives
  • Characterizing the Elimination/Disposition Process (Output)
  • Experimental Design Issues
  • Complicating Factors and Other Issues to Consider
  • Data Analysis: A Worked Example
  • Literature Cited
  • Figures
  • Tables
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Literature Cited

Literature Cited
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