Overview of Glutathione Function and Metabolism

Yvonne Will1

1 Oregon State University, Corvallis, Oregon
Publication Name:  Current Protocols in Toxicology
Unit Number:  Unit 6.1
DOI:  10.1002/0471140856.tx0601s00
Online Posting Date:  May, 2001
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Abstract

Glutathione is a key player in reduction processes in the cell. It is responsible for maintaining thiol groups of intracellular proteins by providing reducing power for cysteine, dihydolipoate, CoA, ascorbate, and vitamin E. It also plays a role in reduction of NTPs to dNTPs. Glutathione is also involved in detoxification of endogenous and exogenous compounds, participates in the synthesis of leukotrienes and prostaglandins, serves as a cofactor for various enzymes, stores and transports cysteine, and may be involved in cell cycle regulation and thermotolerance.

     
 
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Table of Contents

  • Glutathione Function
  • Glutathione Synthesis and Turnover
  • Manipulation of Glutathione Content
  • Mitochondrial Glutathione
  • Literature Cited
  • Figures
     
 
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Literature Cited

Literature Cited
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